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Research Activities


Academic Papers



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Year 2007

M.-R. Ahn, S. Kumazawa, Y. Usui, J. Nakamura, M. Matsuka, F. Zhu, and T. Nakayama: Antioxidant activity and constituents of propolis collected in various areas of China. Food Chem., 101, 1400-1409 (2007)

M.-R. Ahn, K. Kunimasa, T. Ohta, S. Kumazawa, K. Kaji, Y. Uto, H. Hori, H. Nagasawa, and T. Nakayama: Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Lett., 252, 235-243 (2007)

S. Kumazawa, M. Ikenaga, Y. Usui, K. Kajiya, S. Miwa, J. Endo, C. Chikasawa, Y. Suzuki, Y. Suzuki, K. Shimoi, and T. Nakayama: Comprehensive analysis of polyphenols in fruits consumed in Japan. Food Sci. Technol. Res., 13, 404-413 (2007)

Y. Uekusa, M. Kamihira, and T. Nakayama: Dynamic behavior of tea catechins interacting with lipid membranes as determined by NMR spectroscopy. J. Agric. Food Chem., 55, 9986-9992, (2007)

S. Kumazawa, R. Ueda, T. Hamasaka, S. Fukumoto, T. Fujimoto, and T. Nakayama: Antioxidant prenylated flavonoids from propolis collected in Okinawa, Japan. J. Agric. Food Chem., 55, 7722-7725 (2007)

T. Ishii, T. Yamada, T. Mori, S. Kumazawa, K. Uchida, and T. Nakayama: Characterization of acrolein induced protein cross-links. Free Radical Res., 41, 1253-1260 (2007)

K. Kajiya, S. Kumazawa, A. Naitou, and T. Nakayama: Solid-state NMR analysis of the orientation and dynamics of epigallocatechin gallate, a green tea polyphenol, incorporated into lipid bilayers. Magn. Reson. Chem., 46, 174-177 (2008)

K. Murakami, S. Sasaki, Y. Takahash,i K. Uenishi, M. Yamasaki, H. Hayabuchi, T. Goda, J. Oka, K. Baba, K. Ohki, T. Kohri, R. Watanabe, and Y. Sugiyama: Nutrient and food intake in relation to serum leptin concentration among young Japanese women. Nutrition, 23, 461-468 (2007)

K. Mochizuki, N. Sakaguchi, and T. Goda: Triiodothyronine (T3) and fructose coordinately enhance the expression of GLUT5 gene in the small intestine of the weaning rats. Biosci. Biotechnol. Biochem., 71, 1345-1347 (2007):

K. Murakami, S. Sasaki, Y. Takahashi, K. Uenishi, M. Yamasaki, H. Hayabuchi, T. Goda, J. Oka, K. Baba, K. Ohki, T. Kohri, K. Muramatsu, and M. Furuki: Hardness of the habitual diet in relation to body mass index and waist circumference in free-living Japanese women aged 18-22 years. Am. J. Clin. Nutr, 86, 206-213 (2007)

T. Goda, K. Suruga, A. Komori, S. Kuranuki, K. Mochizuki, Y. Makita, and T. Kumazawa: Effects of miglitol, an a-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. Br. J. Nutr., 98, 702-710 (2007)

T. Mitsui, N. Kasezawa, and T. Goda: Milk consumption does not affect body mass index but may have an unfavorable effect on serum total cholesterol in Japanese adults. Nutrition Res., 27, 395-399 (2007)

T. Mitsui, N. Kasezawa, and T. Goda: The healthy alcohol intake for the Japanese population is less than that for Caucasians. Nutrition Res., 27, 478-482 (2007)

M. Shimada, K. Mochizuki, and T. Goda: Dietary supplementation with epigallocatechin gallate elevates the levels of circulating adiponectin in non-obese type 2 diabetic Goto-Kakizaki rats. Biosci. Biotech. Biochem., 71, 2079-2082 (2007)

K. Abe, T. Suzuki, M. Ijiri, Y. Koyama, M. Isemura, and N. Kinae: The anti-fibrotic effect of green tea with a high catechin content in the galactosamine-injured rat liver. Biomed. Res., 28, 43-48 (2007)

H. Takemura, J.Y. Shim, K. Sayama, A. Tsubura, B.T. Zhu, and K. Shimoi: Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. J. Steroid Biochem. Mol. Biol., 103, 170-177 (2007)

Y. Nishio, Y. Nakano, Y. Deguchi, H. Terato, H. Ide, C. Ito, H. Ishida, K. Takagi, H. Tsuboi, N. Kinae, and K. Shimoi: Social Stress Induces Oxidative DNA Damage in Mouse Peripheral Blood Cells. Genes. and Environment., 29, 17-22 (2007)

A. Morita, Y. Iwasaki, K. Kobata, H. Yokogoshi, and T. Watanabe: Newly synthesized oleylgingerol and oleylshogaol activate TRPV1 ion channels. Biosci. Biotechnol. Biochem., 71, 2304-2307 (2007)

Y.Oi-Kano, T. Kawada, T. Watanabe, F. Koyama, K. Watanabe, R. Senbongi and K. Iwai: Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenalinesecretions in rats. J. Nutr. Biochem., 18, 685-692 (2007)

K. Kobata, H. Tate, Y. Iwasaki, Y. Tanaka, K. Ohtsu, S. Yazawa and T. Watanabe: Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1. Phytochemistry, 68, 1179-1184 (2008)

K. Yamada, R. Furuya, T. Takita, Y. Maruyama, Y. Yamaguchi, S. Ohkawa and H. Kumagai: Simplified nutritional screening tools for maintenance hemodialysis patients. Am. J. Clin. Nutr. 87: 106-113 (2008)

H. Kumagai, Y. Yamaguchi, S. Ohkawa, K. Yamada, R. Furuya, T. Takita: Reply to E Cereda and C Pedrolli: The use of the Geriatric Nutritional Risk Index (GNRI) as simplified nutritional screening tool. Am. J. Clin. Nutr. (in press)

T. Oya-Ito, H. Naitou, S. Masuda, N. Kinae, and N. Ohashi: Functional analyses of neutrophil-like differentiated cell lines under a hyperglycemic condition. Mol. Nutr. Food Res. 52, 360-369(2008)

Y. Deguchi, T. Toyoizumi, S. Masuda, A. Yasuhara, S. Mohri S., M. Yamada, Y. Inoue, and N. Kinae: Evaluation of mutagenic activities of leachates in landfill sites by micronucleus test and comet assay using goldfish. Mutat Res, 627(2),178-85 (2007)

K. Ookawa, K. Mochizuki, Y. Sugimoto, T. Suzuki, M. Hashizume, T. Kitagawa, T. Matumoto, C. Ito, and H. Yokogoshi: Effect of ovary lipid of skipjack tuna on rat serum components after stress application. J. Vet. Med. Sci., 69(1), 49-54 (2007)

M. Ohsumi, X. Shi, T. Tuchiya, K. Tujioka, S. Lyou, K. Hayase, and H. Yokogoshi: The role of growth hormone and amino acids on brain protein synthesis in aged rats given proteins of different quantity and quality. Amino Acids, 32(2), 247-253 (2007)

K. Tujioka, S. Okuyama, H. Yokogoshi, Y. Fukaya, K. Hayase, K. Horie, and M. Kim: Dietary gamma-aminobutyric acid affects the brain protein synthesis rate in young rats. Amino Acids, 32(2), 255-260 (2007)

K. Ookawa, K. Mochizuki, Y. Sugimoto, T. Suzuki, M. Hashidume, T. Kitagawa, T. Matumoto, and H. Yokogoshi: Effect of ovary lipids of skipjack tuna (Katsuwonus pelamis) on gastric injury in rats subject to water immersion restraint stress. J. Jpn. Soc. Food Sci. Technol.-Nippon Shokuhin Kagaku Kogaku Kaishi., 53(5), 305-307 (2007)

K. Ookawa, K. Mochizuki, E. Shida, T. Suzuki, T. Suzuki, T. Ooba, T. Matumoto, Y. Hokari, and H. Yokogoshi: Effect of ovary lipid from Skipjack tuna (Katsuwonus pelamis) on brain monoamines in rats. J Vet Med Sci., 69(6), 593-8, (2007)

K. Ookawa, K. Mochizuki, E. Shida, T. Suzuki, T. Suzuki, T. Ooba, T. Matumoto, Y. Hokari, M. Hashidume, and H. Yokogoshi: Anti-anxiety effect of ovary lipid extracted from Skipjack tuna (Katsuwonus pelamis) in rats. J Vet Med Sci., 69(6), 633-6, (2007)

K. Tujioka, M. Ohsumi, K. Hayase, and H. Yokogoshi: Role of growth hormone and amino acids on the brain protein synthesis in rats given proteins of different quantity and quality contained wheat gluten. Amino Acids, 33(3): XXXIII-XXXIV (2007)

K. Tsujioka, M. Ohsumi, K. Hayase,and H. Yokogoshi: Role of growth hormone and amino acids on brain protein synthesis of rats given proteins of different quality and quantity. No.178, 28-33 (2007) Reports of the Research Committee of Essential Amino Acids Japan

T. Yamada, T. Terashima, K. Wada, S. Ueda, M. Ito, T. Okubo, L.R. Juneja, and H. Yokogoshi: Theanine, gammma-glutamylethylamide, increases neurotransmission concentrations and neurotrophin mRNA levels in the brain during lactation. Life Sci. 81 , 1247-1255 (2007)

H. Tazawa, M. Tatemichi, T. Sawa, I. Gilibert, N. Ma, Y. Hiraku, L.A. Donehower, H. Ohgaki, S. Kawanishi, and H. Ohshima: Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerate sarcoma development in Trp53+/- mice. Carcinogenesis, 28(1): 191-8 (2007)

T. Oki, A. Kageyama, Y. Takagi, S. Uchida and S. Yamada: Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder. J. Urol., 177, 766-770 (2007)

M. Suzuki, T. Oki, T. Sugiyama, K. Umegaki, S. Uchida and S. Yamada: Muscarinic and alpha 1-adrenergic receptor binding characteristics of saw palmetto extract in rat lower urinary tract. Urology, 69, 1216-1220 (2007)

S. Uchida, Y. Kato, K. Hirano, Y. Kagawa and S. Yamada: Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine. Life Sci., 80, 1635-1640 (2007)

S. Maruyama, S. Kurosawa, Y. Takagi, T. Oki, Y. Noguchi, M. Ukai, H. Yuyama, A.Ohtake, M. Suzuki, M. Sasayama and S. Yamada: Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstruction. Neurosci. Lett., 414, 80-84 (2007)

S. Uchida, S. Kurosawa, T. Fujino (Oki), Y. Kato, M. Nanri, K. Yoshida and S. Yamada: Binding activities by propiverine and its N-oxide metabolites of voltage-dependent L-type calcium channel antagonist receptors in the rat bladder and brain. Life Sci., 80, 2454-2460 (2007)

S. Yamada, Y. Kato, T. Okura, Y. Kagawa and K. Kawabe: Prediction of alpha1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia. Biol. Pham. Bull., 30, 1237-1241 (2007)

K. Rikimaru, A. Yanagisawa, T. Kan, T. Fukuyama: A versatile synthesis of alpha-amino acid derivatives via the Ugi four-component condensation with a novel convertible isonitrile. Heterocycles, 73, 403-417 (2007)

H. Fuwa, Y. Takahashi, Y. Konno, N. Watanabe, H. Miyashita, M. Sasaki, H. Natsugari, T. Kan, T. Fukuyama, T. Tomita, and T. Iwatsubo: Divergent synthesis of multifunctional molecular probes enabled elucidation of the enzyme specificity of dipeptidic gamma-secretase inhibitors on presenilin-type aspartic proteases. ACS Chemical Biology, 2, 408-418 (2007)

T. Kan, Y. Kita, Y. Morohashi, Y. Tominari, S. Hosoda, H. Natsugari, T. Tomita, T. Iwatsubo and T. Fukuyama: Convenient synthesis of photoaffinity probes and evaluation of their cross-linking abilities. Org. Lett., 9, 2055-2058 (2007)

T. Furuta, Y. Hirooka, A. Abe, Y. Sugata, M. Ueda, K. Murakami, T. Suzuki, K. Tanaka and T. Kan: Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activities. Bioorg. Med. Chem. Lett., 17, 3095-3098 (2007)

A. Takeda, S. Fuke, W. Tsutsumi and N. Oku: Negative modulation of presynaptic activity by zinc released from Schaffer collaterals. J. Neurosci. Res. 85, 3666-3672 (2007)

A. Takeda, S. Fuke, A. Minami and N. Oku: Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release. J. Neurosci. Res. 85, 1310-1317 (2007)

A. Takeda, H. Tamano, F. Kan, H. Itoh and N. Oku: Anxiety-like behavior of young rats after 2-week zinc deprivation. Behav. Brain Res. 177, 1-6 (2007)

A. Takeda, A. Minami, N. Sakurada, S. Nakajima, and N. Oku: Response of hippocampal mossy fiber zinc to excessive glutamate release. Neurochem. Int. 50, 322-327 (2007)

A. Takeda: Involvement of zinc in neuronal death in the hippocampus. Biomed. Res. Trace Elements 18, 204-210 (2007)

A. Takeda, S. Kanno, M. Ando, N. Sakurada, A. Minami and N. Oku: Unique response of extracelluar zinc in the ventral hippocampus against novelty stress. Neurosci. Res. 58 (Suppl. 1), S164 (2007)

T. Maruyama, T. Shiba, H. Iizuka, T. Matsuda, K. Kurohane, and Y. Imai: Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity. Microbiol. Immunol. 51, 321-326 (2007)

T. Maruyama, H. Iizuka, Y. Tobisawa, T. Shiba, T. Matusda, K. Kurohane, and Y. Imai: Influence of local treatments with capsaicin or allyl isotiocyanate in the sensitization phase of an FITC-induced contact sensitivity model. Int. Arch. Allergy Immunol. 143, 144-154 (2007)

T. Tanikawa, K. Kurohane and Y. Imai: Production and characterization of IgA monoclonal antibody against ovalbumin. Hybridoma 26, 328-332 (2007)

T. Harada, M. Miyake, and Y. Imai: Evaluation of Legionella pneumophila from the bactericidal system by reactive oxygen species (ROS) in macrophages. Microbiol. Immunol. 51, 1161-1170 (2007)

M. Nakayama. and N. Yoshimura:(2008) Skill development in a short-term English study abroad program. C. Wong (ed.), Selected papers from the 2006 Annual Research Forum of the Linguistic Society of Hong Kong. 55-66. (2008)

S. Inagaki, T. Noda, J.Z. Min, and T. Toyo'oka: Metabolic profiling of rat hair and screening biomarkers using ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. J. Chromatogr. A, 1176, 94-99 (2007)

S. Satoh, T. Toyo'oka, T. Fukushima, and S. Inagaki: Simultaneous determination of lpha-lipoic acid and its reduced form by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. B, 854, 109-115 (2007)

M. Osabe, J. Sugatani, A. Takemura, Y. Yamazaki, A. Ikari, N. Kitamura, M. Negishi, and M. Miwa: Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation. Biochem. Biophys. Res. Commun., in press (2008)

T. Takahashi, Y. Moriyama, A. Ikari, J. Sugatani, T. Suzuki, and M. Miwa: Surface localization of the nuclear receptor CAR in influenza A virus-infected cells. Biochem. Biophys. Res. Commun., 368(3), 550-555 (2008)

T. Sueyoshi, R. Moore, J. Sugatani, Y. Matsumura, and M. Negishi: PPP1R16A, the membrane subunit of protein phosphatase 1b, signals nuclear translocation of the nuclear receptor CAR. Mol. Pharmacol., in press (2008)

M. Osabe, J. Sugatani, T. Fukuyama, S. Ikushiro, A. Ikari, and M. Miwa: Constitutive androstane receptor and peroxisome proliferator-activated receptor  are activated in liver of male rats fed a high-fat and high-sucrose diet and the hepatic expression of UGT1A1 and UGT1A6 is enhanced. Drug Metab. Dispos., 36(2), 294-302 (2008)

J. Sugatani, K. Mizushima, M. Osabe, K. Yamakawa, S. Kakizaki, H. Takagi, M. Mori, A. Ikari, and M. Miwa: Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. Naunyn Schmiedebergs Arch. Pharmacol., in press (2008)

A, Ikari, C. Okude, H. Sawada, T. Takahashi, J. Sugatani, and M. Miwa: Down- regulation of TRPM6-mediated magnesium influx by cyclosporine A. Naunyn Schmiedebergs Arch. Pharmacol., in press (2008)

A. Ikari, C. Okude, H. Sawada, Y. Sasaki, Y. Yamazaki, J. Sugatani, M. Degawa, and M. Miwa: Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16. Biochim. Biophys. Acta., 1778(1), 283-290 (2008)

A. Ikari, M. Ito, C. Okude, H. Sawada, H. Harada, M. Degawa, H. Sakai, T. Takahashi, J. Sugatani, and M. Miwa: Claudin-16 is directly phosphorylated by protein kinase a independently of a vasodilator-stimulated phosphoprotein-mmediated pathway. J. Cell Physiol.,214, 221-229 (2007)

Y. Kato, S. Ikushiro, R. Takiguchi, K. Haraguchi, N. Koga, S. Uchida, T. Sakaki, S. Yamada, J. Kanno, and M. Degawa: A novel mechanism for polychlorinated biphenyl-mediated decrease in serum thyroxine level in rats. Drug Metab. Dispos., 35(10), 1949-1955 (2007)

Y. Kato, S. Ikushiro, Y. Emi, S. Tamaki, H. Suzuki, T. Sakaki, S. Yamada, and M. Degawa: Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine T4 in humans. Drug Metab. Dispos., 36(1), 51-55 (2008)

M. Kojima, M. Sekimoto, and M. Degawa: Gender-related differences in the level of serum lipids in Meishan pigs. J. Health Sci., 54(1), 97-100 (2008)

M. Kojima, M. Sekimoto, and M. Degawa: A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs. Biochem. Pharmacol., 75(5), 1076-1082 (2008)

C.-T. Guo, N. Takahashi, H. Yagi, K. Kato, T. Takahashi, S.-Q. Yi, Y. Chen, T. Ito, K. Otsuki, H. Kida, Y. Kawaoka, K. I.P.J. Hidari, D. Miyamoto, T. Suzuki, and Y. Suzuki: The quail and chicken intestine have sialyl-Gal sugar chains responsible for the binding of influenza A viruses to human type receptors. Glycobiology 17, 713-724 (2007)

K.I.P.J. Hidari, S. Shimada, Y. Suzuki, and T. Suzuki: Binding kinetics of influenza viruses to sialic acid-containing carbohydrates. Glycoconjugate J. 24, 583-590 (2007)

K. Matsuoka, C. Takita, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K. I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, K. Hatano, and D. Terunuma: Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors.Bioorg. Med. Chem. Lett. 17, 3826–3830 (2007)

J. Sakamoto, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K. I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, Y. Esumi, K. Hatano, D. Terunuma, and K. Matsuoka: Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors. Bioorg. Med. Chem. Lett. 17, 717-721 (2007)

A. Yamada, K. Hatano, T. Koyama, K. Matsuoka, N. Takahashi, K. I.P.J. Hidari, T. Suzuki, Y. Suzuki, and D. Terunuma: Lactotriaose-containing carbosilane dendrimers: Syntheses and lectin-binding activities. Bioorg. Med. Chem. 15, 1606-1614 (2007)

M. Ogata, T. Murata, K. Murakami, T. Suzuki, K. I.P.J. Hidari, Y. Suzuki, and T. Usui: Chemoenzaymatic synthesis of artificial glycopolypeptides containing multivalent sialyloligosaccharides with a γ-polyglutamic acid backbone and their effect on inhibition of infection by influenza viruses. Bioorg. Med. Chem. 15, 1383-1393 (2007)

K. Sato, K. Ikeda, T. Suzuki, S. Aoyama, N. Maki, Y. Suzuki and M. Sato: Synthesis of 4-O-[3-(aryl)prop-2-ynyl]-Neu5Ac2en and its 4-epi-analogs modified at C-4 by Sonogashira coupling reaction. Tetrahedron 63, 7571-7581 (2007)

D. J. Tindal, J. C. Dyason, R. J. Thomson, T. Suzuki, H. Ueyama, Y. Kuwahara, N. Maki, Y. Suzuki, and Mark von Itzstein: Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity. Bioorg . Med. Chem. Lett. 17, 1655-1658 (2007)

P. Auewarakul, O.Suptawiwat, A. Kongchanagul, C.Sangma, Y. Suzuki, K. Ungchusak, S.Louisirirotchanakul, H.Lerdsamran, P. Pooruk, A. Thitithanyanont, C. Pittayawonganon, C.-T. Guo, H. Hiramatsu, W. Jampangern, S. Chunsutthiwat, P. Puthavathana: An avian influenza H5N1 virus binds to a human-type receptor. J. Virol., 81, 9950-9955 (2007)

T. Sawada, T. Hashimoto, H. Nakano, T. Suzuki, Y. Suzuki, Y. Kawaoka, H. Ishida, M. Kiso: Influenza viral hemagglutinin complicated shape is advantageous to its binding affinity for sialosaccharide receptor. Biochem. Biopohys. Res. Commun. 355, 6-9 (2007)

A. Miyatake, M. Fujita, Y. Nagasaka, K. Fujita, M. Tamari, D. Watanabe, N. Nakano, K. I.P.J. Hidari, Y. Suzuki: The new role of disodium cromoglycate in the treatment of adults with bronchial asthma. Allergology International, 56, No.3, 231-239 (2007)

S. Yingsakmongkon, D. Miyamoto, N. Sriwilaijaroen, K. Fujita, K. Matsumoto, W. Jampangern, H. Hiramatsu, C.-T. Guo, T. Sawada, T. Takahashi, K. Hidari, T. Suzuki, M.Ito, Y. Ito, Y. Suzuki: In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume Sieb. et Zucc). Biol. Pharm. Bull. 31(3), 511-515 (2008)

D. Miyamoto, S. Hasegawa, N. Sriwilaijaroen, S. Yingsakmongkon, T. Suzuki, K. I. -P. J. Hidari, T. Takahashi, C.-T. Guo, Y. Sakano and Y. Suzuki: Clarithromycin inhibits progeny virus production from influenza virus – Infected host cells. Biol. Pharm. Bull. 31(2), 217-222 (2008)

T. Abe, H. Morita, H. Noma, T. Kohno, H. Noguchi, and I. Abe: Structure function analysis of benzalacetone synthase from Rheum palmatum., Bioorg. Med. Chem. Lett., 17(11), 3161-3166 (2007) Epub 2007 Mar 15.

I. Abe, H. Morita, S. Oguro, H. Noma, K. Wanibuchi, N. Kawahara, Y. Goda, H. Noguchi, and T. Kohno: Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone, J. Am. Chem. Soc., 129, 5976-5980 (2007)

H. Morita, S. Kondo, S. Oguro, H. Noguchi, S. Sugio, I. Abe, and T. Kohno: Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens, Chemistry & Biology, 14, 1–11, (2007),

I. Abe, H. Tanaka, T. Abe and H. Noguchi: Enzymatic formation of unnatural cytokinin analogs by adenylate-isopentenyl-transferase from mulberry, Biochem. and Biophys. Res. Commun., 355, 795–800 (2007)

K. Wanibuchi, P. Zhang, T. Abe, H. Morita, T. Kohno, G. Chen, H. Noguchi, and I. Abe: An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata., FEBS J. 274(4):1073-1082, (2007)

I. Abe, T. Abe, W. Lou, T. Masuoka, and H. Noguchi: Site-directed mutagenesis of conserved aromatic residuesin rat squalene epoxidase, Biochem. and Biophys. Res. Commun., 352, 259–263 (2007)

H. Morita, S. Kondo, R. Kato, K. Wanibuchi, H. Noguchi, S. Sugio, I. Abe, and T. Khono: Crystallization and preliminary crystallographic analysis of an acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata, Acta Crystallogr. Sect/ F Struct. Biol. Cryst. Commun., 63 (Pt 7), 576-578, (2007)

S.Yonezawa, T. Asai, and N. Oku: Effective tumor regression by antineovascular therapy in hypovascular orthotopic pancreatic tumor model. J. Control. Release, 118, 303-309 (2007)

K. Ichikawa, T. Urakami, S. Yonezawa, H. Miyauchi, K. Shimizu, T. Asai, and N. Oku: Enhanced desensitization efficacy by liposomal conjugation of a specific antigen. Int. J. Pharm., 336, 391-395 (2007)

C. Fuse, Y. Ishida, T. Hikita, T. Asai, and N. Oku: Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma. J. Biol. Chem., 282, 8276-8283 (2007)

Y. Katanasaka, T. Asai, H. Naitou, N. Ohashi, and N. Oku: Proteomic characterization of angiogenic endothelial cells stimulated with cancer cell-conditioned medium. Biol. Pharm. Bull. 30, 2300-2307 (2007)

K. Shimizu, Y. Sawazaki, T. Tanaka, T. Asai, and N. Oku: Chronopharmacologic Cancer Treatment with and Angiogenic Vessel-Targeted Liposomal Drug. Biol. Pharm. Bull. 31, 95-98 (2008)

F. Kawamori, M. Hiroi, T. Harada, K. Ohata, K. Sugiyama, T. Masuda, and N. Ohashi: Molecular typing of Japanese Escherichia coli O157:H7 isolates from clinical specimens by multilocus variable-number tandem repeat analysis and PFGE. J. Med. Microbiol. 57, 58-63 (2008)

Y. Kinoshita, T. Sato, H. Naitou, N. Ohashi, and S. Kumazawa. Proteomic studies on protein oxidation in bonito (Katsuwonus pelamis) muscle. Food Sci. Technol. Res. 13, 133-138 (2007)

K. Kawai, K. Kaku, N. Izawa, M. Shimizu, H. Kobayashi, and T. Shimizu: Herbicide sensitivities of mutated enzymes expressed from artificially generated genes of acetolactate synthase. J. Pestic. Sci., 33 (2008) in press

Year 2008

K. Abe, N. Okada, H. Tanabe, R. Fukutomi, K. Yasui, M. Isemura, N. Kinae: Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats. Biomed. Res. 30, 25-29, 2009

A. Ahmad, I. Kaji, Y. Murakami, N. Funato, T. Ogawa, M. Shimizu, Y. Niwa, H. Kobayashi: Transformation of Arabidopsis with plant-derived DNA sequences necessary for selecting transformants and driving an objective gene. Biosci. Biotechnol. Biochem. 73, 936-938, 2009

M.-R. Ahn, K. Kunimasa, S. Kumazawa, T. Nakayama, K. Kaji, Y. Uto, H. Hori, H. Nagasawa, T. Ohta: Correlation between antiangiogenic activity and antioxidant activity of various components from propolis. Mol. Nutr. Food Res. in press

T. Asai, S. Miyazawa, N. Maeda, K. Hatanaka, Y. Katanasaka, K. Shimizu, S. Shuto, N. Oku: Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC. Cancer Sci. 99, 1029-1033, 2008

T. Asai, Y. Suzuki, S. Matsushita, S. Yonezawa, J. Yokota, Y. Katanasaka, T. Ishida, T. Dewa, H. Kiwada, M. Nango, N. Oku: Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown. Biochem. Biophys. Res. Commun. 368, 243-248, 2008

M.-J. Bae, T. Ishii, K. Minoda, Y. Kawada, T. Ichikawa, T. Mori, M. Kamihira, T. Nakayama: Albumin stabilizes (-)-epigallocatechin gallate in human serum: binding capacity and antioxidant property. Mol. Nutr. Food Res. in press

R. Eguchi, H. Naitou, K. Kunimasa, R. Ayuzawa, Y. Fujimori, N. Ohashi, K. Kaji, T. Ohta: Proteomic analysis of hypoxia-induced tube breakdown of an in vitro capillary model composed of HUVECs: potential role of p38-regulated reduction of HSP27. Proteomics 8, 2897-2906, 2008

S. Fujimoto, K. Mochizuki, M. Shimada, Y. Murayama, T. Goda: Variations in gene expression of inflammatory cytokines in leukocyte-derived cells of high-fat-diet-induced insulin-resistant rats. Biosci. Biotech. Biochem. 72, 2572-2579, 2008

N. Fukaya, K. Mochizuki, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes. Nutr. 21, 1054, 2008

T. Furuta, M. Mochizuki, M. Ito, T. Takahashi, T. Suzuki, T. Kan: Versatile synthesis of head group functionalized phospholipids via oxime bond formation. Org. Lett. 10, 4847-4850, 2008

S. Goto, N. Okada, A. Kaneko, M. Isemura: Different effects of all-trans-retinoic acid on phorbol ester-stimulated and phytohemagglutinin-stimulated interleukin-2 expression in human T-cell lymphoma HUT-78 cells. Cell Struct. Funct. 33, 13-19, 2008

K. Hata, K. Koseki, K. Yamaguchi, S. Moriya, Y. Suzuki, S. Yingsakmongkon, G. Hirai, M. Sodeoka, M. von Itzstein, T. Miyagi: Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. Antimicrob. Agents Chemother. 52, 3484-3491, 2008

T. Hayashi, M. Miyake, T. Fukui, N. Sugaya, T. Daimon, S. Itoh, T. Oku, T. Tsuji, S. Toyoshima, Y. Imai: Exclusion of actin-binding protein p57/coronin-1 from bacteria- containing phagosomes in macrophages infected with Legionella. Biol. Pharm. Bull. 31, 861–865, 2008

T. Hibino, M. Yuzurihara, K. Terawaki, H. Kanno, Y. Kasa, A. Takeda: Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood. J. Pharmacol. Sci. 108, 89-94, 2008

T. Hibino, M. Yuzurihara, H. Kanno, Y. Kasa, A. Takeda: Goshuyuto, a Japanese traditional medicine, and aqueous extracts of Evodiae Fructus constrict isolated rat aorta via adrenergic and/or serotonergic receptors. Biol. Pharm. Bull. 32, 237-241, 2009

K. I.P.J. Hidari, N. Takahashi, M. Arihara, M. Nagaoka, K. Morita, T. Suzuki: Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga. Biochem. Biophys. Res. Commun. 376, 91-95, 2008

K. I.P.J. Hidari, T. Murata, K. Yoshida, Y. Takahashi, Y. Minamijima, Y. Miwa, S. Adachi, M. Ogata, T. Usui, Y. Suzuki, T. Suzuki: Chemoenzymatic synthesis, characterization, and application of glycopolymers carrying lactosamine repeats as entry inhibitors against influenza virus infection. Glycobiology 18, 779-788, 2008

Y. Hirooka, M. Nitta, T. Furuta, T. Kan: Efficient synthesis of optically active gallocatechin-3-gallate derivatives via 6-endo cyclization. Synlett 20, 3234-3238, 2008

K. Honma, K. Mochizuki, T. Goda: Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet. Nutr. 25, 40-44, 2009

Y. Hoshino, T. Urakami, T. Kodama, H. Koide, N. Oku, Y. Okahata, K. J. Shea: Design of synthetic polymer nanoparticles that capture and neutralize toxic peptide. Small 2009, in press

A. Ikari, C. Okude, H. Sawada, Y. Sasaki, Y. Yamazaki, J. Sugatani, M. Degawa, M. Miwa: Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16. Biochim. Biophys. Acta. 1778, 283-290, 2008

A, Ikari, C. Okude, H. Sawada, T. Takahashi, J. Sugatani, M. Miwa: Down- regulation of TRPM6-mediated magnesium influx by cyclosporin A. Naunyn Schmiedebergs Arch. Pharmacol. 377, 333-343, 2008

A. Ikari, C. Okude, H. Sawada, Y. Yamazaki, J. Sugatani, M. Miwa: TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells. Biochem. Biophys. Res. Commun. 369, 1129-1133, 2008

A. Ikari, M. Ito, C. Okude, H. Sawada, H. Harada, M. Degawa, H. Sakai, T. Takahashi, J. Sugatani, M. Miwa: Claudin-16 is directly phosphorylated by protein kinase A independently of a vasodilator-stimulated phosphoprotein-mediated pathway. J. Cell Physiol. 214, 221-229, 2008

H. Imanaka, H. Koide, K. Shimizu, T. Asai, N. K. Shimizu, A. Ishikado, T. Makino, N. Oku: Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake. Biol. Pharm. Bull. 31, 400-404, 2008

S. Inagaki, T. Noda, J.Z. Min, T. Toyo’oka: Ultraperformance liquid chromatography analysis of rat hairs for metabolomic research. Am. Lab. On-Line Edition June-July, 12-15, 2008

M. Inai, T. Goto, T. Furuta, T. Wakimoto, T. Kan: Stereocontrolled total synthesis of (–)-myriocin. Tetrahedron-Asymmetry 19, 2771-2773, 2008

K. Inoue, S. Maruyama, H. Kabeya, N. Yamada, N. Ohashi, Y. Sato, M. Yukawa, T. Masuzawa, F. Kawamori, T. Kadosaka, N. Takada, H. Fujita, H. Kawabata: Prevalence and genetic diversity of Bartonella species isolated from wild rodents in Japan. Appl. Environ. Microbiol. 74, 5086-5092, 2008

T. Ishii, S. Ito, S. Kumazawa, T. Sakurai, S. Yamaguchi, T. Mori, T. Nakayama, K. Uchida: Site-specific modification of positively-charged surfaces on human serum albumin by malondialdehyde. Biochem. Biophys. Res. Commun. 371, 28-32, 2008

Y. Iwasaki, O. Saito, M. Tanabe, K. Inayoshi, K. Kobata, S. Uno, A. Morita, T. Watanabe: Monoacylglycerols activate capsaicin receptor, TRPV1. Lipids 43, 471-483, 2008

K. Kajiya, S. Kumazawa, A. Naitou, T. Nakayama: Solid-state NMR analysis of the orientation and dynamics of epigallocatechin gallate, a green tea polyphenol, incorporated into lipid bilayers. Magn. Reson. Chem. 46, 174-177, 2008

H. Kako, S. Fukumoto, Y. Kobayashi, H. Yokogoshi: Effects of direct exposure of green odour components on dopamine release from rat brain striatal slices and PC12 cells. Brain. Res. Bull. 75, 706-712, 2008

M. Kamihira, H. Nakazawa, A. Kira, Y. Mizutani, M. Nakamura, T. Nakayama: Interaction of tea catechins with lipid bilayers investigated by quartz-crystal microbalance analysis. Biosci. Biotechnol. Biochem. 72, 1372-1375, 2008

T. Kan, Y. Kawamoto, T. Asakawa, T. Furuta, T. Fukuyama: Synthetic studies on altemicidin: stereocontrolled construction of the core framework. Org. Lett. 10, 169-171, 2008

J. Kashimura, Y. Nagai, T. Goda: Inhibitory action of palatinose and its hydrogenated derivatives on the hydrolysis of α-glucosylsaccharides in the small intestine. J. Agr. Food Chem. 56, 5892-5895, 2008

Y. Katanasaka, T. Ida, T. Asai, K. Shimizu, F. Koizumi, N. Maeda, K. Baba, N. Oku: Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416. Cancer Lett. 270, 260-268, 2008

Y. Katanasaka, T. Ida, T. Asai, N. Maeda, N. Oku: Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes. Int. J. Pharm. 360, 219-224, 2008

Y. Kato, S. Ikushiro, Y. Emi, S. Tamaki, H. Suzuki, T. Sakaki, S. Yamada, M. Degawa: Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine in humans. Drug Metab. Dispos. 36, 51-55, 2008

A. Kato, T. Takita, M. Furuhashi, Y. Maruyama, H. Kumagai, A. Hishida: Blood monocyte count is a predictor of total and cardiovascular mortality in hemodialysis patients. Nephron Clin. Pract. 110, 235-243, 2008

F. Kawamori, M. Hiroi, T. Harada, K. Ohata, K. Sugiyama, T. Masuda, N. Ohashi: Molecular typing of Japanese Escherichia coli O157:H7 isolates from clinical specimens by multilocus variable-number tandem repeat analysis and PFGE. J. Med. Microbiol. 57, 58-63, 2008

Y.Kita, T.Toma, T. Kan, T.Fukuyama: Synthetic studies on (+)-manzamine A: Stereo-selective synthesis of the tetracyclic core framework. Org. Lett. 10, 3251-3253, 2008

Y. Kitamura, S. Yoshikawa, T. Furuta, T. Kan: One-pot synthesis of carbazole via tandem Suzuki-Miyaura and amination reaction. Synlett 3, 377-380, 2008

K. Kobata, H. Tate, Y. Iwasaki Y, Y. Tanaka, K. Ohtsu, S. Yazawa, T. Watanabe: Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1. Phytochemistry 69, 1179-1184, 2008

H. Koide, T. Asai, K. Hatanaka, T. Urakami, T. Ishii, E. Kenjo, M. Nishihara, M. Yokoyama, T. Ishida, H. Kiwada, N. Oku: Particle size-dependent triggering of accelerated blood clearance phenomenon. Int. J. Pharm. 362, 197-200, 2008

Y. Koizumi, H. Kobayashi, T. Wakimoto, T. Furuta, T. Fukuyama, T. Kan: Total synthesis of (–)-serotobenine. J. Am. Chem. Soc. 130, 16854-16855, 2008

Y. Koizumi, S. Suzuki, K. Takeda, K. Murahashi, M. Horikawa, K. Katagiri, H. Masu, I. Azumaya, S. Fujii, T. Furuta, K. Tanaka, T. Kan: Synthesis and characteristic stereostructure of a biphenanthryl ether. Tetrahedron-Asymmetry 19, 1407-1410, 2008

M. Kojima, M. Sekimoto, M. Degawa: A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs. Biochem. Pharmacol. 75, 1076-1082, 2008

S. Lyou, S. Kawano, T. Yamada, S. Okuyama, T. Terashima, K. Hayase, H. Yokogoshi: Role of estrogen receptors and aromatase on brain protein synthesis rates in ovariectmized female rats fed genistein. Nutr. Neurosci. 11(4), 155-160, 2008

S. Maruyama, H. Tsukada, S. Nishiyama, T. Kakiuchi, D. Fukumoto, N. Oku, S. Yamada: In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment. J. Pharmacol. Exp. Ther. 325, 774-781, 2008

T. Masuzawa, I. G. Kharitonenkov, Y. Okamoto, T. Fukui, N. Ohashi: Prevalence of anaplasma phagocytophilum and its coinfection with Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province (Russia) - a sympatric region for both tick species. J. Med. Microbiol. 57, 986-991, 2008

E. J. Mitacek, K. D. Brunnemann, M. Suttajit, L. S. Caplan, C. E. Gagna, K. Bhothisuwan, S. Siriamornpun, C. F. Hummel, H. Ohshima, R. Roy, N. Martin: Geographic distribution of liver and stomach cancers in Thailand in relation to estimated dietary intake of nitrate, nitrite, and nitrosodimethylamine. Nutr. Cancer 60, 196-203, 2008

D. Miyamoto, S. Hasegawa, N. Sriwilaijaroen, S. Yingsakmongkon, T. Suzuki, K. I.P.J. Hidari, T. Takahashi, C.-T. Guo, Y. Sakano, Y. Suzuki: Clarithromycin inhibits progeny virus production from human influenza virus – Infected host cells. Biol. Pharm. Bull. 31, 217-222, 2008

N. Miyoshi, E. Watanabe, T. Osawa, M. Okuhira, Y. Murata, H. Ohshima, Y. Nakamura: ATP depletion alters the mode of cell death induced by benzyl isothiocyanate. Biochim. Biophys. Acta. 1782, 566-573, 2008

K. Mochizuki, S. Takabe, T. Goda: Changes of histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone. Biochem. Biophys. Res. Commu. 371, 324-327, 2008

K. Mochizuki, H. Kawai, H. Mochizuki, M. Shimada, S. Takase, T. Goda: Fatty acids in component of milk enhance the expression of the cAMP-response-element- binding-protein-binding-protein (CBP)/p300 gene in developing rats. Br. J. Nutr. 99, 481-486, 2008

T. Mori, T. Ishii, T. Tanaka, D. Mizuno, R. Yamaji, S. Kumazawa, T. Nakayama, M. Akagawa: Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation. Free Radic. Biol. Med. 45, 1384-1394, 2008

K. Motoyama, Y. Nakai, T. Miyashita, Y. Fukui, M. Morita, K. Sanmiya, H. Sakakibara, I. Matsumoto, K. Abe, T. Yakabe, N. Yajima, K. Shimoi: Isolation stress for 30 days alters hepatic gene expression profiles, especially with reference to lipid metabolism in mice. Physiol. Genomics 37, 79-87, 2009

K. Murakami, S. Sasaki, Y. Takahashi , K. Uenishi, M. Yamasaki, H. Hayabuchi, T.Goda, J. Oka, K. Baba, K. Ohki, T. Kohri, R. Watanabe, Y. Sugiyama: Misreporting of dietary energy, protein, potassium, and sodium in relation to body mass index in young Japanese women. Eur. J. Clin. Nutr. 62, 111-118, 2008

Y. Murayama, K. Mochizuki, M. Shimada, Y. Matsuoka, K. Shibata, T. Goda: Effects of wheat albumin consumption on expression of genes related to lipogenesis and insulin sensitivity in adipose tissues of rats. J. Agr. Food Chem. 57, 1606-1611, 2008

M. Nakayama, N. Yoshimura: Japanese EFL Learners’ Skills improvement and the length of study abroad programs. Ars Linguistica 15, 54-64, 2008

K. Ogawa, H. Sakakibara, R. Iwata, T. Ishii, T. Sato, T. Goda, K. Shimoi, S. Kumazawa: Anthocyanin composition and antioxidant activity of the Crowberry (Empetrum nigrum) and other berries. J Agric Food Chem. 56, 4457-4462, 2008

H. Oka, T. Onaga, T. Koyama, C.T. Guo, Y. Suzuki, Y. Esumi, K. Hatano, D. Terunuma, K. Matsuoka: Sialylα(2-3) lactose clusters using carbosilane dendorimer core scaffolds as influenza hemagglutinin blockers. Bioor. Med. Chem. Lett. 18, 4405-4408, 2008

N. Okada, Y. Ishigami, T. Suzuki, A. Kaneko, K. Yasui, R. Fukutomi, M. Isemura: Importins and exportins in cellular differentiation. J. Cell. Mol. Med. 12, 1863-1871, 2008

T. Okura, T. Ozawa, Y. Ito, M. Kimura, Y. Kagawa, S. Yamada: Enhancement by grapefruit juice of morphine antinociception. Biol. Pharm. Bull. 31, 2338-2341, 2008

M. Osabe, J. Sugatani, T. Fukuyama, S. Ikushiro, A. Ikari, M. Miwa: Constitutive androstane receptor and peroxisome proliferator-activated receptor a are activated in liver of male rats fed a high-fat and high-sucrose diet and the hepatic expression of UGT1A1 and UGT1A6 is enhanced. Drug Metab. Dispos. 36, 294-302, 2008

M. Osabe, J. Sugatani, A. Takemura, M. Kurosawa, Y. Yamazaki, A. Ikari, M. Miwa: Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress. FEBS Lett. 583, 885-889, 2009

M. Osabe, J. Sugatani, A. Takemura, Y. Yamazaki, A. Ikari, N. Kitamura, M. Negishi, M. Miwa: Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation. Biochem. Biophys. Res. Commun. 369, 1027-1033, 2008

T. Oya-Ito, H. Naitou, S. Masuda, N. Kinae, N. Ohashi: Functional analyses of neutrophil-like differentiated cell lines under a hyperglycemic condition. Mol. Nutr. Food Res. 52, 360-369, 2008

T. Sakata, R. Furuya, T. Shimazu, M. Odamaki, S. Ohkawa, H. Kumagai.: Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. Blood Purif. 26, 371-378, 2008

T. Sawa, M. Mounawar, M. Tatemichi, I. Gilibert, T. Katoh, H. Ohshima: Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. Cancer Lett. 269, 78-84, 2008

T. Sawada, T. Hashimoto, H. Nakano, T. Suzuki, Y. Suzuki, Y. Kawaoka, H. Ishida, M. Kiso: Ab initio fragment molecular orbital studies of influenza virus hemagglutinin-sialosaccharide complexes toward chemical clarification about the virus host range determination. Glycoconjugate J. 25, 805-815, 2008

T. Shiba, T. Maruyama, K. Kurohane, Y. Iwasaki, T. Watanabe, Y. Imai: TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity. J. Neuroimmunol. 207, 66–74, 2009

M. Shimada, K. Mochizuki, T. Goda: Dietary resistant starch reduces levels of GIP mRNA along the jejunum-ileum in both normal and type 2 diabetic rats. Biosci. Biotech. Biochem. 72, 2206-2209, 2008

M. Shimizu, M. Goto, M. Hanai, T. Shimizu, N. Izawa, H. Kanamoto, KI. Tomizawa, A. Yokota, H. Kobayashi: Selectable tolerance to herbicides by mutated acetolactate synthase genes integrated into the chloroplast genome of tobacco. Plant Physiol. 147, 1976-1983, 2008

T. Sueyoshi, R. Moore, J. Sugatani, Y. Matsumura, M. Negishi: PPP1R16A, the membrane subunit of protein phosphatase 1b, signals nuclear translocation of the nuclear receptor CAR. Mol. Pharmacol. 73, 1113-1121, 2008

J. Sugatani, K. Mizushima, M. Osabe, K. Yamakawa, S. Kakizaki, H. Takagi, M. Mori, A. Ikari, M. Miwa: Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. Naunyn Schmiedebergs Arch. Pharmacol. 377, 597-605, 2008

J. Sugatani, M. Osabe, T. Wada, K. Yamakawa, Y. Yamazaki, T. Takahashi, A. Ikari, M. Miwa: Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high sucrose (cafeteria) diet. Eur. J. Nutr. 47, 192-200, 2008

C. Sugimoto, E. E. Nakayama, T. Shioda, F. Villinger, A. A. Ansari, N. Yamamoto, Y. Suzuki, Y. Nagai, K. Mori: Impact of glycosylation on antigenicity of Simian immunodecficiency virus SIV239: Induction of rapid V1/V2 specific non-neutralizing antibody and delayed neutralizing antibody following infection with an attenuated deglycosylated mutant. J. Gen. Virol. 89, 554-566, 2008

O.Suptawiwat, A. Kongchanagul, W.Chan-It, A. Thitithanyanont, W. Wiriyarat, K. Chaichuen, T. Songserm, Y. Suzuki, P. Puthavathana, P. Auewarakul: A simple screening assay for receptor switching of avian influenza viruses. J. Clinical Virol. 42, 186-189, 2008

T. Suzuki, K. Mochizuki, T. Goda: Histone H3 modifications and Cdx-2 binding to the sucrase-isomaltase (SI) gene is involved in induction of the gene in the transition from the crypt to villus in the small intestine of rats. Biochem. Biophys. Res. Commu. 369, 788-793, 2008

S. Takabe, K. Mochizuki, T. Goda: De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells. Arch. Biochem. Biophys. 475, 1-6, 2008

T. Takahashi, K. Murakami, M. Nagakura, H. Kishita, S. Watanabe, K. Honke, K. Ogura, T. Tai, K. Kawasaki, D. Miyamoto, K. I.P.J. Hidari, C.T. Guo, Y. Suzuki, T. Suzuki: Sulfatide is required for efficient replication of influenza A virus. J. Virol. 82, 5940-5950, 2008

T. Takahashi, Y. Moriyama, A. Ikari, J. Sugatani, T. Suzuki, M. Miwa: Surface localization of the nuclear receptor CAR in influenza A virus-infected cells. Biochem. Biophys. Res. Commun. 368, 550-555, 2008

A. Takeda, H. Tamano, H. Itoh, N. Oku: Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan. Neurochem. Int. 53, 230-235, 2008

A. Takeda, H. Itoh, A. Nagayoshi, N. Oku: Abnormal calcium mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet. Epilepsy Res. 83, 73-80, 2009

A. Takeda, H. Tamano, F. Kan, T. Hanajima, K. Yamada, N. Oku: Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency. Life Sci. 82, 909-914, 2008

A. Takeda, H. Itoh, K. Yamada, H. Tamano, N. Oku: Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on behavior. BioMetals 21, 545-552, 2008

A. Takeda, K. Yamada, H. Tamano, S. Fuke, M. Kawamura, N. Oku: Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency. Neurochem. Int. 52, 241-246, 2008

A. Takeda, S. Fuke, M. Ando, N. Oku: Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar concentrations of zinc. Neurosci. 158, 585-591, 2009

A. Takeda, S. Kanno, N. Sakurada, M. Ando, N. Oku: Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc. J. Neurosci. Res. 86, 2906-2911, 2008

T. Tanaka, A. Suzuki, S. Kuranuki, K. Mochizuki, K. Suruga, S. Takase, T. Goda: Higher expression of jejunal LPH gene in rats fed the high-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 in nuclear proteins to its promoter regions. Life Sci. 83, 122-127, 2008

Y.Tanaka, K.Mochizuki, N.Fukaya, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol suppresses postprandial hyperglycemia and IL-1βand TNF-α gene expression induced in rat peripheral leukocytes by intermittent sucrose loading. Br. J. Nutr. 21, 1054, 2008

T. Taniguchi, T. Harada, T. Hayashi, T. Tanikawa, K. Kurohane, M. Miyake, Y. Imai: Elevated production of Legionella-specific immunoglobulin A in A/J mice is accompanied by T-helper 1-type polarization. Immunol. Lett. 121, 123–126, 2008

T. Tanikawa, T. Ishikawa, T. Maekawa, K. Kurohane, Y. Imai: Characterization of monoclonal immunoglobulin A and G against Shiga toxin binding subunits produced by intranasal immunization. Scand. J. Immunol. 68, 414-422, 2008

S. Uchida, K. Hirai, J. Hatanaka, J. Hanato, S. Yamada: Antinociceptive Effects of St. John’s Wort, Harpagophytum Procumbens extract and grape seed proanthocyanidins extract in mice. Biol. Pharm. Bull. 31, 240-245, 2008

K. Umehara, K. Nemoto, K. Kimijima, A. Matsushita, E. Terada, O. Monthakantirat, W. De-Eknamkul, T. Miyase, T. Warashina, M. Degawa, H. Noguchi: Estrogenic constituents of the heartwood of Dalbergia parviflora. Phytochemistry 69, 546-552, 2008

H. Yagi, N. Yasukawa, S.-Y. Yu, C.-T. Guo, N. Takahashi, T. Takahashi, W. Bukawa, T. Suzuki, K.-H. Khoo, Y. Suzuki, K. Kato: The expression of sialylated high-antennary N-glyeans in edible bird’s nest. Carbohydr. Res. 343, 1373-1377, 2008

K. Yamada, R. Furuya, T. Takita, Y. Maruyama, Y. Yamaguchi, S. Ohkawa, H. Kumagai: Simplified nutritional screening tools for patients on maintenance hemodialysis. Am. J. Clin. Nutr. 87, 106-113, 2008

T. Yamada, T. Terashima, T. Okubo, L. R. Juneja, H. Yokogoshi: Effects of theanine, a unique amino acid in tea leaves, on memory in a rat behavioral test. Biosci. Biotechnol. Biochem. 72, 1356-1359, 2008

S. Yingsakmongkon, D. Miyamoto, N. Sriwilaijaroen, K. Fujita, K. Matsumoto, W. Jampangern, H. Hiramatsu, C.-T. Guo, T. Sawada, T. Tskahashi, K. I.P.J. Hidari, T. Suzuki, M. Ito, Y. Ito, Y. Suzuki: In vitro inhibition of human influenza A virus infection by fruit-juice concentrate of Japanese plum (Prunus mume Sieb. et Zucc). Biol. Pharm. Bull. 31, 511-515, 2008

Year 2009

M.-R. Ahn, K. Kunimasa, S. Kumazawa, T. Nakayama, K. Kaji, Y. Uto, H. Hori, H. Nagasawa, T. Ohta: Correlation between antiangiogenic activity and antioxidant activity of various components from propolis. Mol. Nutr. Food Res. 53, 643-651, 2009

Y. Aihara, A. Yoshida, T. Furuta, T. Wakimoto, T. Akizawa, M. Konishi, T. Kan: Regioselective Synthesis of Methylated Epigallocatechin Gallate via Nitrobenzenesulfonyl (Ns) Protecting Group. Bioorg. Med. Chem. Lett. 19, 4171-4174, 2009

M.-J. Bae, T. Ishii, K. Minoda, Y. Kawada, T. Ichikawa, T. Mori, M. Kamihira, T. Nakayama: Albumin stabilizes (−)-epigallocatechin gallate in human serum: binding capacity and antioxidant property. Mol. Nutr. Food Res. 53 709-715, 2009

N. Fukaya, K. Mochizuki, Y. Tanaka, T. Kumazawa, Z. Jiuxin, M. Fuchigami, T. Goda: The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur. J. Pharmacol. 624, 51-57, 2009

N. Fukaya, K. Mochizuki, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes. Nutr. 25, 657-667, 2009

T. Furuta, H. Onuki, M. Mochizuki, M. Ito, M. Inai, T. Wakimoto, T. Kan: Solid Support Synthesis of Artificial Phospholipids. Synlett 3373-3377, 2009

T. Furuta, M. Nakayama, H. Suzuki, H. Tajimi, M. Inai, H. Nukaya, T. Wakimoto, T. Kan: Concise Synthesis of Chafurosides A and B. Org. Lett. 11. 2233-2236, 2009

J. Hanato, K. Kuriyama, T. Mizumoto, K. Debari, J. Hatanaka, S. Onoue, S. Yamada: Liposomal formulations of glucagon-like peptide-1: Improved bioavailability and anti-diabetic effect. Int. J. Pharm. 382, 111-116, 2009

K. Hatanaka, T. Asai, H. Koide, E. Kenjo, T. Tsuzuku, N. Harada, H. Tsukada, N. Oku: Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography. Bioconjugate Chem. in press

T. Hibino, M. Yuzurihara, Y. Kasa, A. Takeda: Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors. J. Pharmacol. Sci. 111, 73-81, 2009

K. I.P.J. Hidari, M. Ogata, T. Murata, S. Shimada, W. Kozaki, E. Y. Park, T. Suzuki, T. Usui: Chemoenzymatic synthesis of sialoglycopolypeptides as glycomimetics to block infection by avian and human influenza viruses. Bioconjugate Chem. 20, 538–549, 2009

K. I.P.J. Hidari, K. Oyama, G. Ito, M. Nakayama, M. Inai, S. Goto, Y. Kanai, K. Watanabe, K. Yoshida, T. Furuta, T. Kan, T. Suzuki: Identification and characterization of flavonoids as sialyltransferase inhibitors. Biochem. Biophys. Res. Commun. 382, 609-613, 2009

T. Hosaka, M. Sekimoto, K. Nemoto, M. Degawa: Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine. Cancer Sci. 101, 652-657, 2010

Y. Hoshino, T. Urakami, T. Kodama, H. Koide, N. Oku, Y. Okahata, K.-J. Shea: Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide. Small 5, 1562-1568, 2009

A. Ikari , A. Sanada , C. Okude, H. Sawada , Y. Yamazaki , J. Sugatani, M. Miwa: Up-regularion of TRPM6 transcriptional activity by AP-1 in renal epithelial cells. J. Cell. Physiol. 222(3), 481-487, 2010

A. Ikari , K. Kinjo , K. Atomi, Y. Sasaki, Y. Yamazaki, J. Sugatani: Extracellular Mg (2+) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation. Biochim. Biophys. Acta 1798 (3), 415-421, 2010

A. Ikari, K. Atomi, A. Takiguchi, Y. Yamazaki, M. Miwa, J. Sugatani: Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells. Biochem. Biophys. Res. Commun. 384(3), 306-310, 2009

N. Ikegaya, T. Yoshida, T. Kohsaka, A. Suzuki, N. Kobayashi, T. Yamamoto, Y. Fujigaki, A. Hishida, H. Kumagai: Effects of relaxin on development of mesangial proliferative nephritis. Ann. N. Y. Acad. Sci. 1160, 300-303, 2009

Y. Inamochi, K. Mochizuki, A. Osaki, T. Ishii, T. Nakayama, T. Goda: Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression. Biochem. Biophys. Res. Commun. 392, 16-21, 2010

T. Ishii, K. Minoda, M.-J. Bae, T. Mori, Y. Uekusa, T. Ichikawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Binding affinity of tea catechins for human serum albumin: Characterization by high-performance affinity chromatography with immobilized albumin column. Mol. Nutr. Food Res. in press

T. Ishii, M. Wakabayashi, T. Mori, T. Nakayama: A new method for the detection and characterization of α-lipoic acid mixed disulphides. Free Radical Res. 44, 403-409, 2010

T. Ishii, T. Asai, T. Urakami, N. Oku: Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion. Brain Res. 1321, 164-168, 2010

Y. Ito, L. Oyunzul, M. Seki, T. Oki-Fujino, M. Matsui, S. Yamada: Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 single subtype knockout mice. Br. J. Pharmacol. 156, 1147-1153, 2009

Y. Iwasaki, M. Tanabe, Y. Kayama, M. Abe, M. Kashio, K. Koizumi, Y. Okumura, Y. Morimitsu, M. Tominaga, Y. Ozawa, T. Watanabe: Miogadial and miogatrial with a,b-unsaturated 1,4-dialdehyde moieties—Novel and potent TRPA1 agonists. Life Sci. 85, 60-69, 2009

I. Iwashina, K. Mochizuki, Y. Inamochi, T. Goda: Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions. J. Nutr. Biochem. in press

H. Kameji, K. Mochizuki, N. Miyoshi, T. Goda: Beta-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of ROS generation and the suppression of genes related to insulin sensitivity induced by TNF-α. Nutr. in press

M. Kashiwamura, K. Kurohane, T. Tanikawa, A. Deguchi, D. Miyamoto, Y. Imai: Shiga toxin kills epithelial cells isolated from distal but not proximal part of mouse colon. Biol. Pharm. Bull. 32, 1614–1617, 2009

Y. Katanasaka, T. Ishii, T. Asai, H. Naitou, N. Maeda, F. Koizumi, S. Miyagawa, N. Ohashi, N. Oku: Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78. Int. J. Cancer in press

Y. Kato, K. Haraguchi, M. Kubota, M. Seto, T.Okura, S. Ikushiro, N. Koga, S. Yamada, M. Degawa: A possible mechanism for the decrease in serum thyroxine level by a TCDD-like PCB congener, 3,3',4,4',5-pentachlorobiphenyl, in mice. Drug Metab. Dispos. 38(1), 150-156, 2010

M. Kato, N. Shoda, T. Yamamoto, R. Shiratori, T. Toyo'oka: Development of a silica-based double-network hydrogel for high-throughput screening of encapsulated enzymes. Analyst 134, 577-581, 2009

M. Kato, T. Yamamoto, M. Sekimoto, M. Degawa, T. Toyo'oka: An easy cell-based microchip assay method for a CYP1A1-mediated drug metabolism using adhesive HepG2 cells. J. Appl. Phys. 105, 1-4, 2009

M. Kato, Y. Onda, M. Sekimoto, M. Degawa, T. Toyo'oka: A capillary electrochromatography-electron spray ionization-mass spectrometry method for simultaneous analysis of charged and neutral constituents of a hepatocarcinoma cell metabolome. J. Chromatogr. A 1216, 8277-8282, 2009

Y. Kobayashi, H. Kako, H. Yokogoshi: Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of dopamine release from PC12 cells by the green odor compound hexanal. Cell. Mol. Neurobiol. accepted for publication, 2010

H. Koide, T. Asai, K. Hatanaka, S. Akai, T. Ishii, E. Kenjo, T. Ishida, H. Kiwada, H. Tsukada, N. Oku: T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes. Int. J. Pharm. in press

K. Kunimasa, M.-R. Ahn, T. Kobayashi, R. Eguchi, S. Kumazawa, Y. Fujimori, T. Nakano, T. Nakayama, K. Kaji, T. Ohta: Brazilian propolis suppresses angiogenesis by inducing apoptosis in tube-forming endothelial cells through inactivation of survival signal ERK1/2. Evid.-based Complement Altern. Med. in press

S. Kurosawa, S. Uchida Y. Ito, S. Yamada: Effect of ursodeoxycholic acid on the pharmacokinetics and midazolam and CYP3A activity in the liver and small intestine of rats. Xenobiotica 39, 162-170, 2009

P. Luecha, K. Umehara, T. Miyase, H. Noguchi: Antiestrogenic Constituents of the Thai Medicinal Plants Capparis flavicans and Vitex glabrata. J. Nat. Prod. 72(11), 1954–1959, 2009

T. Matsuda, K. Kurohane, Y. Imai: Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice. Toxicol. Lett. 192, 97–100, 2010

S. Misaka, H. Sato, Y. Yamauchi, S. Onoue, S. Yamada: Novel dry powder formulation of Ovalbumin for development of COPD-like animal model: physicochemical characterization and biomarker profiling in rats. Eur. J. Pharm. Sci. 37, 469-476, 2009

Y. Misaki, R. Miyauchi, K. Mochizuki, S. Takabe, M. Shimada, Y. Ichikawa, T. Goda: Plasma IL-1b concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged, non-overweight and overweight Japanese men. Metab. in press

Y, Mizuuchi, S.-P. Shi, K. Wanibuchi, A. Kojima, H. Morita, H. Noguchi, I. Abe: Novel type III polyketide synthases from Aloe arborescens. FEBS J. 276, 2391–2401, 2009

K. Mochizuki, K. Honma, M. Shimada, T. Goda: The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/ low-fat diet in mice. Mol. Nutr. Food Res. 54, 1-7, 2010

K. Mochizuki, E. Hanai, K. Suruga, S. Kuranuki, T. Goda: Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol. Metab. in press

K. Mochizuki, M. Igawa-Tada, S. Takase, T. Goda: Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated galactose on glycosylated chain of S-I complex. Life Sci. 86, 524-531, 2010

H. Morita, Y. Shimokawa, M. Tanio, R. Kato, H. Noguchi, S. Sugio, I. Abe: A structure-based mechanism for benzalacetone synthase from Rheum palmatum. Proc. Natl. Acad. Sci. U.S.A. 107(2), 669-73, 2010

K. Motoyama, Y. Nakai, T. Miyashita, Y. Fukui, M. Morita, K. Sanmiya, H. Sakakibara, I. Matsumoto, K. Abe, T. Yagabe, N. Yajima, K. Shimoi: Isolation stress for 30 days alters hepatic gene expression profiles, especially with reference to lipid metabolism in mice. Physiol. Genomics 37(2), 79-87, 2009

Y. Murase, T. Asai, Y. Katanasaka, T. Sugiyama, K. Shimizu, N. Maeda, N. Oku: A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy. Cancer Lett. 287, 165-171, 2010

Y. Murayama, K. Mochizuki, M. Shimada, Y. Matsuoka, K. Shibata, T. Goda: Effects of wheat albumin consumption on expression of genes related to lipogenesis and insulin sensitivity in adipose tissues of rats. J. Agric. Food Chem. 57, 1606-1611, 2009

Y. Murayama, K. Mochizuki, M. Shimada, S. Fujimoto, K. Nukui, K. Shibata, T. Goda: Dietary supplementation with a-amylase inhibitor wheat albumin to high-fat diet-induced insulin-resistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose tissue. J. Agric. Food Chem. 57, 9332-9338, 2009

M. Ogata, K. I. P. J. Hidari, W. Kozaki, T. Murata, J. Hiratake, E. Y. Park, T. Suzuki, T. Usui: Molecular Design of Spacer-N-Linked Sialoglycopolypeptide as Polymeric Inhibitors Against Influenza Virus Infection. Biomacromolecules 10, 1894-1903, 2009

H. Oka, T. Onaga, T. Koyama, C.-T. Guo, Y. Suzuki, Y. Esumi, K. Hatano, D. Terunuma, K. Matsuoka: Syntheses and biological evaluations of carbosilane dendrimers uniformly functionalized with sialyl α2→3) lactose moieties as inhibitors for human influenza viruses. Bioorg. Med. Chem. 17, 5465-5475, 2009

S. Onoue, H. Sato, Y. Kawabata, T. Mizumoto, N. Hashimoto, S. Yamada: In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy. J. Controlled Release 138, 16-23, 2009

M. Osabe, J. Sugatani, A. Takemura, M. Kurosawa, Y. Yamazaki, A. Ikari, M. Miwa: Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress. FEBS Lett. 583(5), 885-889, 2009

Y. Osada, R. Miyauchi, T. Goda, N. Kasezawa, H. Horiike, M. Iida, S. Sasaki, K. Yamakawa-Kobayashi: Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination. J. Hum. Genet. 54, 474-478, 2009

Y. Sakai, K. Ikeuchi, Y. Yamada, T. Wakimoto, T. Kan: Modified Julia-Kocienski Reaction Promoted by Means of m-NPT (Nitrophenyltetrazole) sulfone. Synlett 827-829, 2010

H. Sakakibara, T. Ogawa, A. Koyabagi, S. Kobayashi, T. Goda, S. Kumazawa, H. Kobayashi, K. Shimoi: Distribution and excretion of bilberry anthocyanines. J. Agric. Food Chem. 57(17), 7681-7686, 2009

J. Sakamoto, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K. I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, Y. Esumi, T. Nakamura, K. Hatano, D. Terunuma, K. Matsuoka: Systematic syntheses of influenza neuraminidase inhibitors: A series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties. Bioorg. Med. Chem. 17, 5451-5464, 2009

N. Sakurai, K. Mochizuki, H. Kameji, M. Shimada, T. Goda: (-)-Epigallocatechin gallate enhances the expression of gene related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation. Nutr. 25, 1047-1056, 2009

Y. Seto, S. Onoue, S. Yamada: In vitro/In vivo phototoxic risk assessments of griseofulvin Based on photobiochemical and disposition behaviors. Eur. J. Pharm. Sci. 38, 104-111, 2009

S.-P. Shi, K. Wanibuchi, H. Morita, K. Endo, H. Noguchi, I. Abe: Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone scaffolds by plant type III polyketide synthase. Org. Lett. 10, 551–554, 2009

S.-P. Shi, H. Morita, K. Wanibuchi, H. Noguchi, I. Abe: Enzymatic formation of unnatural novel polyketide scaffolds by plant-specific type III polyketide synthase. Tetrahedron Lett. 50, 2150–2153, 2009

M. Shimada, K. Mochizuki, T. Goda: Feeding rats dietary resistant starch shifts the peak of SGLT1 gene expression and histone H3 acetylation on the gene from the upper jejunum towards the ileum. J. Agric. Food Chem. 57, 8049-8055, 2009

M. Shimizu, H. Kato, T. Ogawa, A. Kurachi, Y. Nakagawa, H. Kobayashi: Sigma factor phosphorylation in the photosynthetic control of photosystem stoichiometry. Proc. Natl. Acad. Sci. U.S.A. 107, in press

K. Shimizu, M. Osada, K. Takemoto, Y. Yamamoto, T. Asai, N. Oku: Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane. J. Controlled Release 141, 208-215, 2010

K. Shimizu, N.K. Shimizu, W. Hakamata, K. Unno, T. Asai, N. Oku: Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice. Biol. Pharm. Bull. 33,117-121, 2010

N. Sriwilaijaroen, P. Wilairat, H. Hiramatsu, T. Takahashi, T. Suzuki, M. Ito, Y. Ito, M. Tashiro, Y. Suzuki: Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities. Virol. J. 06, 124, 2009

J. Sugatani, M. Osabe, M. Kurosawa, N. Kitamura, A. Ikari, M. Miwa: Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: Cell-cycle dependent expression. Drug Metab. Dispos. 38(1), 177-186, 2010

S. W. Suh, S. J. Won, A. M. Hamby, Y. Fan, C. T. Sheline, H. Tamano, A. Takeda, J. Liu: Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J. Cereb. Blood Flow Metab. 29, 1579-1588, 2009

K. Suzuki, J. Sakamoto, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, D. Terunuma, K. Matsuoka: Synthesis of sialic acid derivatives having a C=C double bond substituted at the C-5 position and their glycopolymers. Bioorg. Biomed. Chem. Lett. 19, 5105-5108, 2009

T. Suzuki, K. Mochizuki, T. Goda: Localized expression of genes related to carbohydrate and lipid absorption along the crypt-villus axis of rat jejunum. Biochim. Biophys. Acta 1790, 1624-1635, 2009

H. Takahama, T. Minamino, H. Asanuma, M. Fujita, T. Asai, M. Wakeno, H. Sasaki, H. Kikuchi, K. Hashimoto, N. Oku, M. Asakura, J. Kim, S. Takashima, K. Komamura, M. Sugimachi, N. Mochizuki, M. Kitakaze: Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats. J. Am. Coll. Cardiol. 53, 709-717, 2009

T. Takahashi, A. Hashimoto, M. Maruyama, H. Ishida, M. Kiso, Y. Kawaoka, Y. Suzuki, T. Suzuki: Identification of amino acid residues of influenza A virus H3 HA contributing to the recognition of molecular species of sialic acid. FEBS Lett. 583, 3171-3174, 2009

A. Takeda, H. Iwaki, M. Ando, K. Itagaki, M. Suzuki, N. Oku: Zinc Differentially Acts on Components of Long-term Potentiation at Hippocampal CA1 Synapse. Brain Res. in press

A. Takeda, H. Itoh, A. Nagayoshi, N. Oku: Abnormal calcium mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet. Epilepsy Res. 83, 73-80, 2009

A. Takeda, M. Ando, S. Kanno, N. Oku: Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation. Neurotoxicol. 30, 712-717, 2009

A. Takeda, N. Sakurada, M. Ando, S. Kanno, N. Oku: Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus. Neurochem. Int. 55, 376-382, 2009

A. Takeda, S. Fuke, M. Ando, N. Oku: Positive Modulation of Long-term Potentiation at Hippocampal CA1 Synapses by Low Micromolar Concentrations of Zinc. Neurosci. 158, 585-591, 2009

Y. Taki, Y. Yamazaki, F. Shimura, S. Yamada, K. Umegaki: Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. J. Pharmacol. Sci. 109, 459-462, 2009

H. Tamano, F. Kan, M. Kawamura, N. Oku, A. Takeda: Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation. Neurochem. Int. 55, 536-541, 2009

Y. Tanaka, K. Mochizuki, N. Fukaya, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol suppresses postprandial hyperglycemia and IL-1β and TNF-α gene expression induced in rat peripheral leukocytes by intermittent sucrose loading. Br. J. Nutr. 102, 221-225, 2009

Y. Tanaka, M. Hosokawa, K. Otsu, T. Watanabe, S. Yazawa: Assessment of capsiconinoid composition, nonpungent capsaicinoid analogues, in Capsicum cultivars. J. Agric. Food Chem. 57, 5407-5412, 2009

Y. Tobisawa, Y. Imai, M. Fukuda, H. Kawashima: Sulfation of colonic mucins by N-acetylglucosamine-6-O-sulfotransferase-2 and its protective function in experimental colitis in mice. J. Biol. Chem. 285(9). 6750-6760, 2010

S. Tomono, N. Miyoshi, K. Sato, Y. Ohba, H. Ohshima: Formation of cholesterol ozonolysis products through an ozone-free mechanism mediated by the myeloperoxidase-H2O2-chloride system. Biochem. Biophys. Res. Commun. 383(2), 222-227, 2009

K. Umehara, K. Nemoto, A. Matsushita, E. Terada, O. Monthakantirat, W. De-Eknamkul, T. Miyase, T. Warashina, M. Degawa, H. Noguchi: Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parWiflora and their effects on estrogenic-responsive human breast cancer cells. J. Nat. Prod. 72, 2163-2168, 2009

T. Urakami, K. Sakai, T. Asai, D. Fukumoto, H. Tsukada, N. Oku: Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography. Nucl. Med. Biol. 36, 295-303, 2009

T. Urakami, T. Kawaguchi, S. Akai, K. Hatanaka, H. Koide, K. Shimizu, T. Asai, D. Fukumoto, N. Harada, H. Tsukada, N. Oku: In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography. Artif. Organs. 33, 164-168, 2009

T. Wakimoto, M. Nitta, K. Kasahara, T. Chiba, Y. Ye, K. Tsuji, T. Kan, H. Nukaya, M. Ishiguro, M. Koike, Y. Yokoo, Y. Suwa: Structure-activity relationship study on a 1 adrenergic receptor antagonists from beer. Bioorg. Med. Chem. Lett. 19, 5905-5908, 2009

M. Watanabe, H. Tamano, T. Kikuchi, A. Takeda: Susceptibility to Stress in Young Rats after 2-week Zinc Deprivation. Neurochem. Int. 56, 410-416, 2010

Wuritu, Y. Ozawa, Gaowa, F. Kawamori, T. Masuda, T. Masuzawa, H. Fujita, N. Ohashi: Structural analysis of a p44/msp2 expression site of Anaplasma phagocytophilum in naturally infected ticks in Japan. J. Med. Microbiol. 58, 1638-1644, 2009

S. Yamada, C. Takeuchi, L. Oyunzul, Y. Ito: Bladder angiotensin-II receptors: Characterization and alteration in bladder outlet obstruction. Eur. Urol. 55, 482-489, 2009

T. Yamada, T. Terashima, R. Kawano, R. Furuno, T. Okubo, L. R. Juneja, H. Yokogoshi: Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. Amino Acids 36(1), 21-27, 2009

T. Yamada, Y. Yamada, Y. Okano, T. Terashima, H. Yokogoshi: Anxiolytic effects of short- and long-term administration of cacao mass on rat elevated T-maze test. J. Nutr. Biochem. 20, 948-955, 2009

N. Yamaguchi, S. Miyamoto, Y. Ogura, T. Goda, K. Suruga: Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein type II gene expression in intestinal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 296, 524-533, 2009

T. Yamauchi, Y. Johzuka-Hisatomi, S. Fukada-Tanaka, R. Terada, I. Nakamura, S. Iida: Homologous recombination-mediated knock-in targeting of the MET1a gene for maintenance DNA methyltransferase reproducibly reveals dosage-dependent spatiotemporal gene expression in rice. Plant J. 60, 386-396, 2009

K. Yasui, H. Tanabe, N. Okada, R. Fukutomi, Y. Ishigami, M. Isemura: Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats. Biomed. Res. in press

S. Yokoshima, Y. Abe, N. Watanabe, Y. Kita, T. Kan, T. Iwatsubo, T. Tomita, T. Fukuyama: Development of Photoaffinity Probes for γ-Secretase Equipped with a Nitrobenzenesulfonamide-type Cleavable Linker. Bioorg. Med. Chem. Lett. 20, 1798-1799, 2010

A. Yokoyama, H. Sakakibara, A. Crozier, Y. Kawai, A. Matsui, J. Terao, S. Kumazawa, K. Shimoi: Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Free Radical Res. 43(10), 913-921, 2009

N. Yoshimura, M. Nakayama: Nominative case marking and verb inflection in L2 grammar: Evidence from Japanese college students’ composition. In Otsu, Yukio (ed.) The Proceedings of the 2009 Tokyo Conference on Psycholinguistics 359-383. Tokyo: Hituzi Syobo, 2009

N. Yoshimura, M. Nakayama: Acquisition of two types of -s by Japanese EFL Learners: The role of L1 transfer. In Y-S. Yang, S-W. Tang, C. Kim, J-Y. Yoon, Y-S. Kang, K-A. Kim, H. Yoo, Y. Jang, and H-K. Kang (eds.), Current Issues in Linguistic Interfaces 2. 253-263. Seoul, Korea: Hankook Munhwasa. 2009

Year 2010

Y. Ohmichi, J. Hirakawa, Y. Imai, M. Fukuda, H. Kawashima: Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses. J. Exp. Med., 208, 1015-1025 (2011)

T. Wakimoto, T. Asakawa, S. Akahoshi, T, Suzuki, K. Nagai, H. Kawagishi, T. Kan: Proof the existence of an unstable amino acid, pleurocybellaziridine, in Pleurocybella porrigens (angel’s wing mushroom). Angew. Chem. Int. Ed., 50, 1168-1170 (2011)

M. Shimizu, H. Kato, T. Ogawa, A. Kurachi, Y. Nakagawa, and H. Kobayashi: Sigma factor phosphorylation in the photosynthetic control of photosystem stoichiometry. Proc. Natl. Acad. Sci. USA, 107, 10760-10764 (2010)

C. A. Nidom, R. Takano, S. Yamada, Y. Sakai-Tagawa, S. Daulay, D. Aswadi, T. Suzuki, Y. Suzuki, K. Shinya, K. Iwatsuki-Horimoto, Y. Muramoto, Y. Kawaoka: Influenza A (H5N1) viruses from pigs, Indonesia. Emerg. Infect. Dis. 16, 1515-1523 (2010)

N. Miyoshi, T. Nagasawa, R. Mabuchi, Y. Yasui, K. Wakabayashi, T. Tanaka, Ohshima H: Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin. Cancer Prev. Res., (2011) in press

A. Yoshida, Y. Hirooka, Y. Sugata, M. Nitta, T. Manabe, S. Ido, K. Murakami, R. K. Saha, T. Suzuki, M. Ohshima, A. Yoshida, K. Itoh, K. Shimizu, N. Oku, T. Furuta, T. Asakawa, T. Wakimoto, T. Kan: Concise synthesis of catechin probes enabling analysis and imaging of EGCg. Chem Commun, 47, 1794-1796 (2011)

T. Asakawa, A. Hiza, M. Nakayama, M. Inai, D. Oyama, H. Koide, K. Shimizu, T. Wakimoto, N. Harada, H. Tsukada, N. Oku, T. Kan: PET Imaging of Nobiletin Based on a Practical Total Synthesis. Chem Commun, 47, 2868 – 2870 (2011)

T. Higashi, Y. Isobe, H. Ouchi, H. Suzuki, Y. Okazaki, T. Asakawa, T. Furuta, T. Wakimoto, T. Kan: Stereocntrolled Synthesis of (+)-Methoxyphenylkainic acid and (+)-Phenylkainic acid. Org. Lett., 13, 1089-1091 (2011)

J. Hirakawa, K. Tsuboi, K. Sato, M. Kobayashi, S. Watanabe, A. Takakura, Y. Imai, Y. Ito, M. Fukuda, H. Kawashima: Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycan in lymphocyte homing. J. Biol. Chem., 285, 40864-40878 (2010)

Y. Tobisawa, Y. Imai, M. Fukuda, H. Kawashima: Sulfation of colonic mucins by N-acetylglucosamine-6-O-sulfotransferase-2 and its protective function in experimental colitis in mice. J. Biol. Chem., 285, 6750–6760 (2010)

T. Suzuki, V. Douard, K. Mochizuki, T. Goda, R. Ferraris: Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter GLUT5 during development of rat small intestine. Biochem. J., 435, 43-53 (2011)

K. Koyama, A. Ito, J. Yamamoto, T. Nishio, J. Kajikuri, Y. Dohi, N. Ohte, A. Sano, H. Nakamura, H. Kumagai, T. Itoh: Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis. Am J Kidney Dis. 55, 1069-1078 (2010)

H. Tsutsui, T. Maeda, T. Toyo'oka, J.Z. Min, S. Inagaki, T. Higashi, Y. Kagawa: Practical analytical approach for the identification of biomarker candidates in prediabetic state based upon metabonomic study by ultra-performance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry. J. Proteome Res., 9, 3912-3922 (2010)

S. Tomono, N. Miyoshi, H. Shiokawa, T. Iwabuchi, Y. Aratani, T. Higashi, H. Nukaya, H. Ohshima: Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway, J. Lipid. Res., 52(1): 87-97, (2011)

M. Watanabe, T. Hirokawa, T. Kobayashi, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto: Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy. J. Med. Chem., 53: 3585-3593 (2010)

K. Kawai, K. Kaku, N. Izawa, M. Shimizu, H. Kobayashi, and T. Shimizu: Transformation of Arabidopsis by mutated acetolactate synthase genes from rice and Arabidopsis that confer specific resistance to pyrimidinylcarboxylate-type ALS inhibitors. Plant Biotech., 27, 75-84 (2010)

Y. Katanasaka, T. Ishii, T. Asai, H. Naitou, N. Maeda, F. Koizumi, S. Miyagawa, N. Ohashi, N. Oku: Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78. Int. J. Cancer 127, 2685-2698 (2010)

A. Ikari, A. Sanada, C. Okude, H. Sawada, Y. Yamazaki, J. Sugatani, M. Miwa: Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells. J Cell Physiol. 222, 481-487 (2010)

A. Ikari, A. Takiguchi, K. Atomi, T. Sato, J. Sugatani: Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells. J Cell Physiol, in press

M. Sakaguchi, T. Ohura, T. Iwata, S Takahashi, S. Akai, T. Kan, H. Murai, M. Fujiwara, O. Watanabe, M. Narita: Diblock Copolymer of Bacterial Cellulose and Poly(methyl methacrylate) Initiated by Chain-End-Type Radicals Produced by Mechanical Scission of Glycosidic Linkages of Bacterial Cellulose. Biomacromolecules ACS, 11, 3059-3066 (2010)

T. Ishii, K. Minoda, M.-J. Bae, T. Mori, Y. Uekusa, T. Ichikawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Binding affinity of tea catechins for HSA: Characterization by high-performance affinity chromatography with immobilized albumin column. Mol. Nutr. Food Res., 54, 816-822 (2010)

K. Mochizuki, K. Honma, M. Shimada, T. Goda: The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/ low-fat diet in mice. Mol. Nutr. Food Res., 54, 1445-1451 (2010)

N. Sriwilaijaroen, S. Kondo, H. Yagi, N. Takemae, T. Saito, H. Hiramatsu, K. Kato, Y. Suzuki: N-glycans from porcine trachea and lung: Predominant NeuAcα2-6Gal could be a selective pressure for influenza variants in favor of human-type receptor. PLoS ONE, 6, issue 2, e-16302 (2011)

T. Hayashi, M. Nakamichi, H. Naitou, N. Ohashi, Y. Imai, M. Miyake: Proteomic analysis of growth phase-dependent expression of Legionella pneumophila proteins for identifying novel virulence-associated factors. PLoS One 22, e11718 (2010)

T. Hayashi, M. Nakamichi, H. Naitou, N. Ohashi, Y. Imai, M. Miyake: Proteomic analysis of growth phase-dependent expression of Legionella pneumophila proteins which involves regulation of bacterial virulence traits. PLoS One, 5, e11718 (2010)

T. Takahashi, Y. Kurebayashi, K. Ikeya, T. Mizuno, K. Fukushima, H. Kawamoto, Y. Kawaoka, Y. Suzuki, T. Suzuki: The Low-pH Stability Discovered in Neuraminidase of 1918 Pandemic Influenza A Virus Enhances Virus Replication. PLoS One 5 (12), e15556 (2010)

N. Miyoshi, Y. Wakao, S. Tomono, M. Tatemichi, T. Yan, H. Ohshima: The enhancement of the oral bioavailability of γ-tocotorienol in mice by γ-cyclodextrin inclusion. J. Nutr. Biochem., (2011) in press

I. Iwashina, K. Mochizuki, Y. Inamochi, T. Goda: Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions. J. Nutr. Biochem., 22, 334-343 (2011)

T. Furuta, J. Yamamoto, Y. Kitamura, A. Hashimoto, H. Masu, I. Azumaya, T. Kan, T. Kawabata: Synthesis of Axially Chiral Amino Acid and Amino Alcohols via Additive-Ligand-Free Pd-Catalyzed Domino Coupling Reaction and Subsequent Transformations of the Product Amidoaza[5]helicene. J. Org. Chem., 75, 7010-7013, (2010)

T. Itoh, H. Takemura, K. Shimoi, K. Yamamoto K: A 3D model of CYP1B1 explains the Dominant 4-hydroxylation of estradiol, J. Chem. Inf. Model, 50(6), 1173-1178 (2010)

T. Hosaka, M. Sekimoto, K. Nemoto, M. Degawa: Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine. Cancer Sci.,101, 652-657 (2010)

S. Yamada, Y. Ito, Y. Taki, M. Seki, M. Nanri, F. Yamashita, K. Morishima, I. Komoto, K. Yoshida: The N-oxide metabolite contributes to bladder selectivity resulting from oral propiverine: muscarinic receptor binding and pharmacokinetics. Drug Metab. Dis.. 38: 1314-1321 (2010)

J. Sugatani, M. Osabe, M. Kurosawa, N. Kitamura, A. Ikari, M. Miwa: Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2. Drug Metab. Dispos. 38, 177-186 (2010)

J. Sugatani, S. Sadamitsu, M. Kurosawa, S. Ikushiro, T. Sakaki, A. Ikari, M. Miwa: Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats. Drug Metab. Dispos. 38, 1655-1664 (2010)

Y. Kato, K. Haraguchi, M. Kubota, Y. Seto, T. Okura, S. Ikushiro, N. Koga, S. Yamada, M. Degawa: A possible mechanism for the decrease in serum thyroxine level by a 2,3,7,8-tetrachlorodibenzo- p-dioxin-like polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl in mice. Drug Metab. Dispos., 38, 150-156 (2010)

Y. Kato, K. Haraguchi, Y. Ito, A. Fujii, T. Yamazaki, T. Endo, N. Koga, S.Yamada, M. Degawa: Polychlorinated biphenyl-mediated decrease in serum thyroxine level in rodents. Drug Metab. Dispos., 38, 697-704 (2010)

D. Kato, S. Era, I. Watanabe, Ma. Arihara, N. Sugiura, K. Kimata, Y. Suzuki, K. Morita, K. I.P.J. Hidari, T. Suzuki: Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein. Antiviral Res. 88, 236-243 (2010)

R. K. Saha, T. Takahashi, Y. Kurebayashi, K. Fukushima, A. Minami, N. Kinbara, M. Ichitani, Y. M. Sagesaka, T. Suzuki: Antiviral effect of strictinin on influenza virus replication. Antiviral Res. 88, 10-18 (2010)

A. Ikari , K. Kinjo , K. Atomi, Y. Sasaki, Y. Yamazaki, J. Sugatani: Extracellular Mg (2+) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation. Biochim Biophys Acta 1798 (3), 415-421 (2010)

M. Ando, N. Oku, A. Takeda: Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin. Neurochem. Int., 57, 608-614 (2010)

M. Watanabe, H. Tamano, T. Kikuchi, A. Takeda: Susceptibility to stress in young rats after 2-week zinc deprivation. Neurochem. Int., 56, 410-416 (2010)

T. Matsuda, K. Kurohane, Y. Imai: Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice. Toxicol. Lett., 192, 97–100 (2010)

M. Hiroi, Y. Nagahara, R. Miyauchi, Y. Misaki, T. Goda, N. Kasezawa, S. Sasaki, K. Yamakawa-Kobayashi: The Combination of Genetic Variations in the PRDX3 Gene and Dietary Fat Intake Contribute to Obesity Risk. Obesity (Dec 2. 2010, Epub ahead of print)

Y. Kato, H. Suzuki, K. Haraguchi, S. Ikushiro, Y. Ito, S. Uchida, S. Yamada, M. Degawa: A possible mechanism for the decrease in serum thyroxine level by phenobarbital in rodents. Toxicol. Appl. Pharmacol., 249, 238-246 (2010)

A. Takeda, H. Tamano, S. Imano, N. Oku: Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fear. Neuroscience, 168, 715-722 (2010)

A. Takeda, S. Takada, M. Ando, K. Itagaki, H. Tamano, M. Suzuki, H. Iwaki, N, Oku: Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol. Neuroscience, 171, 443-450 (2010)

D. A. Boltz, B. Douangngeun, P. Phommachanh, S. Sinthasak, R. Mondry, C. Obert, P. Seiler, R. Keating, Y. Suzuki, H. Hiramatsu, E. A. Govorkova, R. G. Webster: Emergence of H5N1 Avian Influenza Viruses with Reduced Sensitivity to Neuraminidase Inhibitors and Novel Reassortants in LAO PDR. J. Gen Virol., 91, 949-959 (2010)

N. Takemae, R. Ruttanapumma, S. Parchariyanon, S. Yoneyama, T. Hayashi, H. Hiramatsu, N. Sriwilaijaroen, Y. Uchida, S. Kondo, H. Yagi, K. Kato, Y. Suzuki, T. Saito: Alterations in receptor binding properties of swine influenza viruses of H1 subtype after isolation in embryonated chicken eggs. J. Gen. Virol., 91, 938-948 (2010)

K. Tomiyama, H. Nakashima, Y. Arakawa, H. Kumagai: Mechanism underlying the olfactory disturbance induced by an intraperitoneal injection of tributyltin chloride in rats. Toxicology. 276, 110-114 (2010)

H. Takemura, H. Nagayoshi, T. Matsuda, H. Sakakibara, M. Morita, A. Matsui, T. Ohura, K. Shimoi: Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells, Toxicol., 274(1-3), 42-48. (2010)

H. Sakakibara,CPN. Romanowski, V. Jakubcakova, C. Flachskamm, K. Shimoi, M. Kimura: Feeble awake effects of plasminogen activator inhibitor type-1 in mice. Behav. Brain Res., in press.

N. Sriwilaijaroen, A. Kadowaki, Y. Onishi, N. Gato, M. Ujike, T. Odagiri, M. Tashiro, Y. Suzuki: Mumefural and related HMF derivatives from Japanese apricot fruit juice concentrate show multiple inhibitory effects on pandemic influenza A (H1N1) virus. Food Chem., 127, 1-9 (2011)

M. Saito, E. Kazuyama, S. Shimizu, F. Dimitriadis, Y. Kinoshita, E. Masuda, S. Yamada, K. Satoh: Muscarinic receptors and their mRNAs in type 2 Goto-Kakizaki diabetic rat prostate. Prostate, 70: 1533-1539 (2010)

T. Watanabe, K. Ohnuki, K. Kobata: Studies on the metabolism and toxicology of emerging capsinoids.Expert Opinion Drug Metab. Toxicol. (2011) in press

R. Saito, S. Ohkawa, S. Ichinose, M. Nishikino, N. Ikegaya, H. Kumagai: Validity of mid-arm muscular area measured by anthropometry in nonobese patients with increased muscle atrophy and variation of subcutaneous fat thickness. Eur J Clin Nutr. 64, 899-904 (2010)

J. Hatanaka, H. Chikamori, H. Sato, S. Uchida, K. Debari, S. Onoue, S. Yamada: Physicochemical and pharmacological characterization of a-tocopherol loaded nano-emulsion system. Int. J. Pharm., 396: 188-193 (2010)

S. Onoue, H. Takahashi, Y. Kawabata, Y. Seto, J. Hatanaka, B.N. Timmermann, S. Yamada: Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. J. Pharm. Sci., 99: 1871-1881 (2010)

M. Kojima, M. Sekimoto, M. Degawa: Androgen-mediated down-regulation of CYP1A subfamily genes in the pig liver. J. Endocrinol., 207, 203-211 (2010)

T. Ishii, T. Mori, T. Ichikawa, M. Kaku, K. Kusaka, Y. Uekusa, M. Akagawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin. Bioorg. Med. Chem., 18, 4892-4896, (2010)

H. Takemura, T. Itoh, K. Yamamoto, H. Sakakibara, K. Shimoi: Selective inhibition of methoxyflavonoids on human CYP1B1 activity, Bioorg. Med. Chem., 18(17), 6310-6315 (2010)

Y. Sakai, K. Ikeuchi, Y. Yamada, T. Wakimoto, T. Kan: Modified Julia-Kocienski Reaction Promoted by Means of m-NPT (Nitrophenyltetrazole) sulfone. SYNLETT, 827-827 (2010)

S. Ieda, T. Kan, T. Fukuyama: Synthesis of the Optically Active Key Intermediate of FR901483. Tetrahedron Letters 51, 4027-4029, (2010)

H. Takemura, H. Uchiyama, T. Ohura, H. Sakakibara, R. Kuruto, T. Amagai, K. Shimoi: A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells, J. Steroid Biochem. Mol. Biol., 118(1-2), 70-76 (2010)

H. Kameji, K. Mochizuki, N. Miyoshi, T. Goda: β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of ROS generation and the suppression of genes related to insulin sensitivity induced by TNF-α. Nutrition, 26, 1151-1156 (2010)

K. Mochizuki, E. Hanai, K. Suruga, S. Kuranuki, T. Goda: Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol. Metabolism, 59, 1442-1447 (2010)

K. Mochizuki, N. Fukaya, Y. Tanaka, M. Fuchigami, T. Goda: Treatment with the α-glucosidase inhibitor miglitol from the pre-onset stage in OLETF rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes. Metabolism, in press (2011)

K. Mochizuki, Y. Misaki, R. Miyauchi, S. Takabe, M. Shimada, N. Miyoshi, Y. Ichikawa, T. Goda: Circulating interleukin-1β and interleukin-6 concentrations are closely associated with γ-glutamyltranspeptidase activity in middle-aged Japanese men without obvious cardiovascular diseases. Metabolism, in press (2010)

T. Osonoi, M. Saito, K. Mochizuki, N. Fukaya, T. Muramatsu, S. Inoue, M. Fuchigami, T. Goda: The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes. Metabolism, 59, 1816-1822 (2010)

Y. Misaki, R. Miyauchi, K. Mochizuki, S. Takabe, M. Shimada, Y. Ichikawa, T. Goda: Plasma interleukin-1β concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged non-overweight and overweight Japanese men. Metabolism, 59, 1465-1471 (2010)

H. Kako, Y. Kobayashi, H. Yokogoshi: Effects of n-hexanal on dopamine release in the striatum of living rats. Eur J Pharmacol., 2010

A. Ikari, K. Atomi, K. Kinjo, Y. Sasaki, J. Sugatani: Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. Life Sci. 86, 766-773 (2010)

A. Yoshida, S. Maruyama, D. Fukumoto, H. Tsukada, Y. Ito, S. Yamada: Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography. Life Sci., 25: 175-180 (2010)

K. Mochizuki, M. Igawa-Tada, S. Takase, T. Goda: Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated galactose on glycosylated chain of S-I complex. Life Sci., 86, 524-531 (2010)

S. Fujimoto, K. Mochizuki, M. Shimada, T. Hori, Y. Murayama, N. Ohashi, T. Goda: Insulin resistance induced by a high-fat diet is associated with the induction of genes related to leukocyte activation in rat peripheral leukocytes. Life Sci. 87, 679-685 (2010)

S. Fujimoto, T. Goda, K. Mochizuki: In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice. Biochem. Biophys. Res. Commu., 404, 223-227 (2011)

Y. Inamochi, K. Mochizuki, A. Osaki, T. Ishii, T. Nakayama, T. Goda: Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression. Biochem. Biophys. Res. Commu., 392, 16-21 (2010)

H. Tsutsui, T. Maeda, J.Z. Min, S. Inagaki, T. Higashi, Y. Kagawa, T. Toyo’oka: Biomarker discovery in biological specimens (plasma, hair, liver and kidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Clin. Chim. Acta, in press

K. Mochizuki, Y. Sato, S. Takase, T. Goda: Changes in mucosal α-glucosidase activities along the jejunal-ileal axis by an hm-HACS diet intake are associated with decreased lipogenic enzyme activity in epididymal adipose tissue. J. Agr. Food Chem., 58, 6923-6927 (2010)

M. Shimada, K. Mochizuki, T. Goda: Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histones on the Thrsp gene in the jejunum. J. Agr. Food Chem., 59, 1464-1469 (2011)

K. Kobata, K. Saito, H. Tate, A. Nashimoto, H. Okuda, I. Takemura, K. Miaykawa, M. Takahashi, K. Iwai, T. Watanabe: Long chain N-vanillyl-acylamides from Capsicum oleoresin. J. Agric. Food Chem. 58, 3627-3631 (2010)

Y. Terada, M. Narukawa, T. Watanabe: Specific hydroxyl fatty acids in royal jelly activate TRPA1. J. Agric.Food Chem. (2011) in press

A. Takeda, H. Iwaki, M. Ando, K. Itagaki, M. Suzuki, N. Oku: Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapse. Brain Res., 1323, 59-64 (2010)

A. Takeda, M. Suzuki, H. Tamano, M. Ando, N. Oku: Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components. Brain Res., 1354: 188-195 (2010)

T. Higashi, T. Ichikawa, S. Inagaki, J.Z. Min, T. Fukushima, T. Toyo’oka: Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Pharm. Biomed. Anal., 52, 809-818 (2010)

M. Shinohara, K. Uchida, S. Shimada, K. Tomioka, N. Suzuki, T. Minegishi, S. Kawahashi, Y. Yoshikawa, N. Ohashi: Novel concentration method for detection of norovirus and sapovirus from water using minute particles of amorphous calcium phosphate. J. Med. Microbiol. in press.

T. Ishii, M. Wakabayashi, T. Mori, T. Nakayama: A new method for the detection and characterization of α-lipoic acid mixed disulphides. Free Radic. Res., 44, 403-409 (2010)

H. Tamano, F. Kan, N. Oku, A. Takeda: Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice. Brain Res. Bull., 83, 351-355 (2010)

T. Matsuda, T. Maruyama, H. Iizuka, A. Kondo, T. Tamai, K. Kurohane, Y. Imai: Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice. Food Chem. Toxicol., 48, 1704–1708 (2010)

Y. Kobayashi, H. Kako, H. Yokogoshi: Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of dopamine release from PC12 cells by the green odor compound hexanal. Cellular and Molecular Neurobiology, 30, 173-184 (2010)

T. Takahashi, H. Satoh, M. Takaguchi, S. Takafuji, H. Yokoyama, S. Fujii, T. Suzuki: Binding of sulfatide to recombinant hemagglutinin of influenza A virus produced by a baculovirus protein expression system. J. Biochem. 147, 459-462 (2010)

M. Takaguchi, T. Takahashi, C. Hosokawa, H. Ueyama, K. Fukushima, T. Hayakawa, K. Itoh, K. Ikeda, T. Suzuki: A single amino acid mutation at position 170 of human parainfluenza virus type 1 fusion glycoprotein induces obvious syncytium formation and caspase-3-dependent cell death. J. Biochem. 149, 191-202 (2011)

S. Misaka, S. Uchida, H. Imai, N. Inui, S. Nishio, K. Ohashi, H. Watanabe, S. Yamada: Pharmacokinetics and pharmacodynamics of low doses of midazolam administered intravenously and orally to healthy volunteers. Clin. Exp. Pharmacol. Physiol., 37: 290-295 (2010)

S. PIYAVIRIYAKUL, K. Shimizu, T. Asakawa, T. Kan, P. SIRIPONG, N. Oku: Anti-angiogenic activity and intracellular distribution of epigallalocatechin-3-gallate analogs. Biol. Pharm. Bull., 34, 396-400 (2011)

T. Tanikawa, K. Kurohane, Y. Imai: Regulatory effect of lysophosphatidic acid on lymphocyte migration. Biol. Pharm. Bull., 33, 204–208 (2010)

T. Yamanaka, K. Tsujimura, T. Kondo, T. Matsumura, H. Ishida, M. Kiso, K. IP J. Hidari, T. Suzuki: Infectivity and pathogenicity of canine H3N8 influenza a virus in horses. Influenza Other Respi. Viruses 4, 345-351 (2010)

Y-L Lai, S. Aoyama, R. Nagai, N. Miyoshi, H. Ohshima: Inhibitation of L-Arginine Metabolizing Enzymes by L-Arginine-derived Advanced Glycation End Products. J. Clin. Biochem. Nutr., 46:177-85, 2010

Year 2011

S. Akai, S. Ishida, K. Hatanaka, T. Ishii, N. Harada, H. Tsukada, N. Oku: Synthesis of long-chain [18F]deoxyfluoropoly(ethylene glycol) methyl ethers and their non-invasive pharmacokinetic analysis by positron emission tomography. Mol. Pharm. 8, 302-308, 2011.

T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, N. Oku: Dicetyl phosphate-tetraetylenepentamine- based liposomes for systemic siRNA delivery. Bioconjug. Chem. 22, 429-435, 2011.

J. M. Barichello, S. Kizuki, T. Tagami, T. Asai, T. Ishida, H. Kikuchi, N. Oku, H. Kiwada: Agitation during lipoplex formation improves the gene knockdown effect of siRNA. Int. J. Pharm. 410, 153-160, 2011.

J. Chen, S. Yamada, Y. Hama, A. K. Shetty, T. Kobayashi, H. Oda, K. Seiki, E. Kim, T. Kimura, N. Takahashi, K. I.P.J. Hidari, T. Suzuki, Y. Suzuki, K. Sugahara: Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus. Biochem. Biophys. Res. Commun. 412(1) 136-142, 2011.

K. Fukushima, T. Takahashi, T. Masahiro, H. Ueyama, S. Ito, Y. Kurebayashi, T. Kawanishi, J.L. Mckimm-Breschkin, T. Takimoto, A. Minami, T. Suzuki: Plaque formation assay for human parainfluenza virus type 1. Biol. Pharm. Bull. 34, 996-1000, 2011.

R. Furuya, H. Kumagai, T. Miyata, H. Fukasawa, S. Isobe, N. Kinoshita, A. Hishida: High plasma pentosidine level is accompanied with cardiovascular events in hemodialysis patients. Clin. Exp. Nephrol. 16, Dec 9 2011.

Gaowa, Wuritu, D. Wu, Y. Yoshikawa, N. Ohashi, F. Kawamori1, K. Sugiyama, M. Ohtake, M. Ohashi, S. Yamamoto, T. Kitano, N. Takada, H. Kawabata: Detection and characterization of p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected ticks and wild deer in Japan, Jpn. J. Infect. Dis. in press.

S. Haramizu, F. Kawabata, K. Ohnuki, N. Inoue, T. Watanabe, S. Yazawa, T. Fushiki: Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice. Biomed. Res. 32(4), 279-284, 2011.

M. Hayashi-Tsugane, M. Maekawa, Q. Qian, H. Kobayashi, S. Iida, K. Tsugane: A rice mutant displaying a heterochronically elongated internode carries a 100 kb deletion. J. Genet. Genomics 38, 123-128, 2011.

M. Hayashi-Tsugane, M. Maekawa, H. Kobayashi, S. Iida, K. Tsugane: Examination of transpositional activity of nDart1 at different stages of rice development. Genes Genet. Syst. 86, 215-219, 2011.

T. Higashi, M. Suzuki, J. Hanai, S. Inagaki, J. Z. Min, K. Shimada, T. Toyo’oka: A specific LC/ESI-MS/MS method for determination of 25-hydroxyvitamin D3 in neonatal dried blood spots containing a potential interfering metabolite, 3-epi-25-hydroxyvitamin D3. J. Sep. Sci. 34, 725-732, 2011.

T. Higashi, T. Ichikawa, C. Shimizu, S. Nagai, S. Inagaki, J. Z. Min, H. Chiba, S. Ikegawa, T. Toyo’oka: Stable isotope-dilution liquid chromatography/tandem mass spectrometry method for determination of thyroxine in saliva. J. Chromatogr. B. 879, 1013-1017, 2011.

Y. Higuchi, K. Sage-Ono, R. Sasaki, N. Ohtsuki, A. Hoshino, S. Iida, H. Kamada, M. Ono: Constitutive expression of the GIGANTEA ortholog affects circadian rhythms and suppresses one-shot induction of flowering in Pharbitis nil, a typical short-day plant. Plant Cell Physiol. 52, 638-650, 2011.

M. Hiroi, T. Harada, F. Kawamori, N. Takahashi, T. Kanda, K. Sugiyama, T. Masuda, Y. Yoshikawa, N. Ohashi: A survey of β-lactamase-producing Escherichia coli in farm animals and raw retail meat in Shizuoka prefecture, Japan. Jpn. J. Infect. Dis. 64, 153-155, 2011.

Y. Hoshino, H. Koide, K. Furuya , W.W. Haberaecker, S.H. Lee, T. Kodama, H. Kanawaza, N. Oku, K.J. Shea: The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo. Proc. Natl. Acad. Sci. USA, 109, 33-38, 2012.

A. Ikari, A. Sanada, H. Sawada, C. Okude, C. Tonegawa, J. Sugatani: Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells. Biochim. Biophys. Acta. 1808, 1502-1508, 2011.

A. Ikari, A. Takiguchi, K. Atomi, J. Sugatani: Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2 protein in MDCK II cells. J. Cell. Physiol. 226, 2448-2456, 2011.

A. Ikari, A. Takiguchi, K. Atomi, T. Sato, J. Sugatani: Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells. J. Cell. Physiol. 226, 1471-1478, 2011.

A. Ikari, H. Sawada, A. Sanada, C. Tonegawa, Y. Yamazaki, J. Sugatani: Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21Cip1 and p27Kip1 in renal epithelial NRK-52E cells. J. Cell. Biochem. 112, 3563-3572, 2011.

A. Ikari, T. Sato, A. Takiguchi, K. Atomi, Y. Yamazaki, J. Sugatani: Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells. Life Sci. 88, 628-633, 2011.

M. Imai, T. Watanabe, M. Hatta, S-C Das, M. Ozawa, K. Shinya, G. Zhong, A. Hanson, H. Katsura, S. Watanabe, C. Li, E. Kawakami, S. Yamada, M. Kiso, Y. Suzuki, E-A Maher, G. Neumann, Y. Kawaoka: Experimental adaptation of an influenza H5 haemagglutinin confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature, in press.

S. Inagaki, H. Hirashima, S. Taniguchi, T. Higashi, J. Z, Min, R. Kikura-Hanajiri, Y. Goda, T. Toyo’oka: Rapid enantiomeric separation and simultaneous determination of phenethylamines by ultra high-performance liquid chromatography with fluorescence and mass spectrometric detection: application to the analysis of illicit drugs distributed in the Japanese market and biological samples. Drug Test. Anal. in press.

S. Inoue, K. Mochizuki, T. Goda: Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes. J. Nutr. Sci. Vitaminol., 57, 162-169, 2011.

T. Ishii, Y. Ichikawa, K. Minoda, K. Kusaka, S. Ito, Y. Suzuki, M. Akagawa, K. Mochizuki, T. Goda, T. Nakayama: Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization. Biosci. Biotechnol. Biochem., 75, 100-106, 2011.

K. Ito, S. Ito, T. Shimamura, S. Weyand, Y. Kawarasaki, T. Misaka, K. Abe, T. Kobayashi, A.D. Cameron, S. Iwata: Crystal structure of glucansucrase from dental caries pathogen Streptococcus mutans. J. Mol. Biol. 408, 177-186, 2011.

Y. Iwasaki, Y. Tamura, K. Inayoshi, M. Narukawa, K. Kobata, H. Chiba, E. Muraki, N. Tsunoda, T. Watanabe: Effect of monoacylglycerol on diet-induced obesity in mice. Biosci. Biotechnol. Biochem. 75(5), 904-909, 2011.

Y. Johzuka-Hisatomi, H. Noguchi, S. Iida: The molecular basis of incomplete dominance at the A locus of CHS-D in the common morning glory, Ipomoea purpurea. J. Plant Res. 124, 299-304, 2011.

T. Kanehira, Y. Nakamura, K. Nakamura, K. Horie, N. Horie, K. Furugori, Y. Sauchi, H. Yokogoshi: Relieving occupational fatigue by consumption of a beverage containing γ–amino butyric acid. J. Nutr. Sci. Vitaminol. 57, 9-15, 2011.

Y. Kato, M. Onishi, K. Haraguchi, S. Ikushiro, C. Ota, N. Koga, T. Endo, S. Yamada, M. Degawa: A possible mechanism for 2,2',4,4',5,5'-hexa- chlorobiphenyl-mediated decrease in serum thyroxine level in mice. Toxicol. Appl. Pharmacol. 254, 48-55, 2011.

K. Kimata, M. Yamaguchi, Y. Saito, H. Hata, K. Miyake, T. Yamane, Y. Nakagawa, A. Yano, K. Ito, Y. Kawarasaki: High cell-density expression system: A novel method for extracellular production of "difficult-to-express" proteins. J. Biosci. Bioeng. 113, 154-159, 2012.

K. Kobata, M. Mimura, M. Sugawara, T. Watanabe: Synthesis of stable isotope-labeled precursors for the biosyntheses of capsaicinoids, capsinoids, and capsiconinoids. Biosci. Biotechnol. Biochem. 75(8), 1611-1614, 2011.

A. Kobayashi, H. Yokoyama, J. Kataoka, T. Ishida, H. Kuno, S. Sugai, H. Sakakibara, K. Shimoi: Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats. J. Toxicol. Sci. 36(3), 325-37, 2011.

C. Kobayashi, K. Kurohane, Y. Imai: High dose dietary pyridoxine induces T-helper type 1 polarization and decreases contact hypersensitivity response to fluorescein isothiocyanate in mice. Biol. Pharm. Bull. in press.

H. Koide, T. Asai, K. Furuya, T. Tsuzuku, H. Kato, T. Dewa, M. Nango, N. Maeda, N. Oku: Inhibition of Akt(ser473) Phosphorylation and Rapamycin-Resistant Cell Growth by Knockdown of Mammalian Target of Rapamycin with Small Interfering RNA in Vascular Endothelial Growth Factor Receptor-1-Targeting Vector. Biol. Pharm. Bull. 34, 602-608, 2011.

T. Kojima, N. Nagao, D. Ando, T. Ojima, Y. Kawarasaki, I. Kobayashi, M. Nakajima, H. Nakano: Emulsion culture: A miniaturized library screening system based on micro-droplets in an emulsified medium. J. Biosci. Bioeng.112, 299-303, 2011.

M. Kojima, T. Ashino, T. Yoshida, Y. Iwakura, M. Degawa: Interleukin-1 controls the constitutive expression of the Cyp7a1 gene by regulating the expression of Cyp7a1 transcriptional regulators in the mouse liver. Biol. Pharm. Bull. 34, 1644-1647, 2011.

YL. Lai, S. Aoyama, M. Ohata, N. Otsuka, H. Shiokawa, S. Tomono, Y. Fujiwara, H. Kanazawa, N. Miyoshi, H. Ohshima: Dysregulation of dimethylargininedimethylaminohydrolase/asymmetricdimethylarginine pathway in rat type II diabetic nephropathy. J.Clin.Biochem.Nutr. in press.

YL. Lai, S. Tomono, N. Miyoshi, H. Ohshima: Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases. J. Clin. Biochem. Nutr. 50, 84-89, 2012.

R. Mabuchi, A. Kurita, N. Miyoshi, A. Yokoyama, T. Furuta, T. Goda, Y. Suwa, T. Kan, T. Amagai, H. Ohshima: Analysis of -ethyllysine in human plasma proteins by gas chromatography- negative ion chemical ionization/mass spectrometry as a biomarker for exposure to acetaldehyde and alcohol. Alcohol. Clin. Exp. Res. in press.

S. Matsumoto, T. Asakawa, Y. Hamashima, T. Kan: A Short-step Asymmetric Synthesis of Dehydrodiconiferyl Alcohol by Means of C-H Insertion Reaction. Synlett, in press.

K. Matsumoto, T. Takeuchi, N. Yokoyama, Y. Katagiri, M. Ooshiro, S. Zakimi, Gaowa, F. Kawamori, N. Ohashi, H. Inokuma: Detection of the new Ehrlichia species closely related to Ehrlichia ewingii from Haemaphysalis longicornis in Yonaguni Island, Okinawa, Japan. J. Vet. Med. Sci., 73, 1485-1488, 2011.

J. Z. Min, H. Yano, A. Matsumoto, H-f Yu, Q. Shi, T. Higashi, S. Inagaki, T. Toyo’oka: Simultaneous determination of polyamines in human nail as 4-(N,N-dimethylaminosulfonyl)-7-fluoro- 2,1,3-benzoxadiazole derivatives by nano-flow chip LC coupled with quadrupole time-of-flight tandem mass spectrometry. Clin. Chim. Acta. 412, 98-106, 2011.

J. Z. Min, S. Hatanaka, H-f Yu, T. Higashi, S. Inagaki, T. Toyo’oka: Determination of DL-amino acids, derivatized with R(-)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, in nail of diabetic patients by UPLC-ESI-TOF-MS. J. Chromatogr. B 879, 3220-3228, 2011.

J. Z. Min, Y. Suzuki, Y. Tomiyasu, D. Jin, T. Higashi, Y-I Lee, T. Toyo’oka: Development of novel active acceptors possessing a positively charged structure for the transglycosylation reaction with Endo-M and their application to oligosaccharide analysis. Rapid. Commun. Mass Spectrom. 25, 2911-2922, 2011.

A. Minami, H. Shimizu, Y. Meguro, N. Shibata, H. Kanazawa, K. Ikeda, T. Suzuki: Imaging of sialidase activity in rat brain sections by a highly sensitive fluorescent histochemical method. NeuroImage, 58, 34-40, 2011.

S. Misaka, R. Nakamura, S. Uchida, K. Takeuchi, N. Takahashi, N. Inui, K. Kosuge, S. Yamada, Hiroshi Watanabe: Effect of two weeks consumption of pomegranate juice on the pharmacokinetics of single dose of midazolam: an open-labeled, randomized, single-center, two-period crossover study in healthy Japanese volunteers. Clin Therap. 33, 246-252, 2011.

K. Miyamoto, S. Higashino, K. Mochizuki, T. Goda, K. Koyama: Evaluation of weight loss in the community-dwelling elderly with dementia as assessed by eating behavior and mental status. Asia Pac. J. Clin. Nutr. 20, 9-13, 2011.

K. Mochizuki, A. Ishihara, T. Goda, K. Yamauchi: RNA polymerase II phosphorylation at serine 2 and histone H3 tri-methylation at lysine 36 are key steps for thyroid hormone receptor b gene activation by thyroid hormone in Rana catesbeiana tadpole liver. Biochem. Biophys. Res. Commu. in press.

K. Mochizuki, R. Miyauchi, Y. Misaki, Y. Ichikawa, T. Goda: Principal component 1 score calculated from metabolic syndrome diagnostic parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic diseases. Eur. J. Nutr., in press.

K. Mochizuki, Y. Misaki, R. Miyauchi, S. Takabe, M. Shimada, K. Kuriki, Y. Ichikawa, T. Goda: A higher rate of eating is associated with higher circulating IL-1b concentrations in Japanese men without treatment for metabolic diseases. Nutrition, in press.

K. Nemoto, S. Ito, C. Yoshida, M. Miyata, M. Kojima, M. Degawa: Hepatic expression of spermatogenic genes and their transiently remarkable downregulations in Wistar-Kyoto rats in response to lead nitrate-administration: strain-difference in the gene expression patterns. J. Toxicol. Sci, 36, 357-364, 2011.

K. Nishikawa, T. Asai, H. Shigematsu, K. Shimizu, H. Kato, Y. Asano, S. Takashima, E. Mekada, N. Oku, T. Minamino :Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer. J. Control. Release, 2011.

R. Nishino, K. Ikeda, T. Hayakawa, T. Takahashi, T. Suzuki, M. Sato: Syntheses of 2-deoxy-2, 3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1. Bioorg. Med. Chem. 19, 2418-2427, 2011.

M. Ogata, M. Yano, M. Umemura, S. Murata, T., Park EY, Y. Kobayashi, T. Asai, N. Oku, N. Nakamura, I. Matsuo, T. Usui: Design and Synthesis of High-Avidity Tetravalent Glycoclusters as Probes for Sambucus sieboldiana Agglutinin and Characterization of their Binding Properties. Bioconjug Chem. 23, 97-105, 2012.

Y. Ohhara, Y. Kayashima, Y. Hayashi, S. Kobayashi, K. Yamakawa-Kobayashi: Expression of β-adrenergic-like octopamine receptors during Drosophila development. Zoolog.Sci. 29, 83-89, 2011.

S. Ohno, M. Hosokawa, A. Hoshino, Y. Kitamura, Y. Morita, K. I. Park, A. Nakashima, A. Deguchi, F. Tatsuzawa, M. Doi, S. Iida, S. Yazawa: A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin systhesis in dahlia (Dahlia variabilis) . J. Exp. Bot. 62, 5105-5116, 2011.

N. Oku, M. Yamashita, Y. Katayama, T. Urakami, K. Hatanaka, K. Shimizu, T. Asai, H. Tsukada, S. Akai, H. Kanazawa: PET imaging of brain cancer with positron emitter-labeled liposomes. Int. J. Pharm. 403, 170-177, 2011.

S. Okuyama, K. Tashiro, N-V Lam, T. Hatakeyama, T. Terashima, H. Yokogoshi: Effect of the edible mushroom Mycoleptodonoides aitchisonii on transient global ischemia-induced monoamine metabolism changes in rat cerebral cortex. J. Med. Food, 15(1), 96-99, 2012.

S. Onoue, A. Uchida, H. Takahashi, Y. Seto, Y. Kawabata, K. Ogawa, K. Yuminoki, N. Hashimoto, S. Yamada: Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability. J Pharm Sci. 100, 3793-3801, 2011.

S. Onoue, Y. Seto, M. Ochi, R. Inoue, H. Ito, T. Hatano, S. Yamada: In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts. Phytochemistry. 72, 1814-1820, 2011.

M. Pervin, N. Paeng, K. Yasui, S. Imai, M. Isemura, H. Yokogoshi, T. Nakayama: Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine. J. Sci. Food Agric. in press.

K. Sakai-Kato, T. Hasegawa, A. Takaoka, M. Kato, T. Toyo’oka, N. Utsunomiya-Tate, T. Kawanishi: Controlled structure and properties of silicate nanoparticle networks for incorporation of biosystem components. Nanotechnology, 22, 205702 (pp1-8), 2011.

K. Shintaku, K. Uchida, Y. Suzuki, M. Kashio, Z. Yiming, Y. Takayama, T. Fushiki, T. Watanabe, S. Yazawa, M. Tominga: Activation of TRPA1 by a non-pungent capsaicin-like compound, capsiate. Br. J. Pharmacol. in press.

Y. Suzuki, N. Miyoshi, M. Isemura: Health-promoting effects of green tea. Proc. Japan Acad. Ser B. in press.

K. Suzuki, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, K. Matsuoka: Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors. Bioorganic & Medicinal Chemistry, 20, 446-454, 2012.

Y. Takanami, T. Nakayama: Evaluation of superoxide anion radicals generated from aqueous extract of particulate phase cigarette smoke by electron spin resonance using 5,5-dimethyl-1-pyrroline-N-oxide. Biosci. Biotechnol. Biochem. 75, 34-39, 2011.

A. Takeda, H. Tamano, T. Ogawa, S. Takada, M. Ando, N. Oku, M. Watanabe: Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency. Behav. Brain Res. 226, 259-264, 2012.

A. Takeda, H. Tamano, M. Suzuki, K. Sakamoto, N. Oku, H. Yokogoshi: Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response. Cell. Mol. Neurobiol. 32, 41-48, 2012.

A. Takeda, K. Itagaki, M. Ando, N. Oku: Involvement of NMDA receptor subunits in zinc-mediated modification of CA1 LTP in the developing hippocampus. J. Neurosci. Res. 90, 551-558, 2012.

A. Takeda, K. Sakamoto, H. Tamano, K. Fukura, N. Inui, S. W. Suh, S-J Won, H. Yokogoshi: Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. Cell. Mol. Neurobiol. 31, 1079-1088, 2011.

A. Takeda, M. Suzuki, H. Tamano, S. Takada, K. Ide, N. Oku: Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress. Neurochem. Int. in press.

A. Takeda, S. Takada, M. Nakamura, M. Suzuki, H. Tamano, M. Ando, N. Oku: Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficit. PLoS One, 6, e28615, 2011.

Y. Taki, E. Hagiwara, C. Hirose, K. Shinozuka, K. Umegaki, S. Yamada: Effects of Ginkgo biloba extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats. J. Pharm. Pharmacol. 63, 1238-1243, 2011.

T. Tanaka, T. Ishii, D. Mizuno, T. Mori, R. Yamaji, Y. Nakamura, S. Kumazawa, T. Nakayama, M. Akagawa: (-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68. Free Radic. Biol. Med. 50, 1324-1335, 2011.

T. Tanikawa, K. Kurohane, Y. Imai: Regulatory Effect of Cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis. Biol. Pharm. Bull. 34, 1090-1093, 2011.

Y. Tobisawa, T. Maruyama, T. Tanikawa, K. Nakanishi, K. Kurohane, Y. Imai: Establishment of recombinant hybrid-IgG/IgA immunoglobulin specific for Shiga toxin. Scand. J. Immunol. 76, 574-584. 2011.

K. Tokutomi, T. Tagawa, M. Korenaga, M. Chiba, T. Asai, N. Watanabe, S. Takeoka, M. Handa, Y. Ikeda, N. Oku: Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets. Int. J. Pharm. 407, 151-157, 2011.

S. Tomono, N. Miyoshi, M. Ito, T. Higashi, H. Ohshima: A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine. J. Chromatogr. B. 879, 2802-2808, 2011.

H. Tsuboi, H. Sakakibara, K. Yamakawa-Kobayashi, A. Tatsumi, T. Inamori, R. Hamamoto, A. Suzuki, K. Shimoi: Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress. J. Affect. Disorders, 134(1-3), 448-485, 2011.

K. Tsujioka, M. Ohsumi, K. Sakamoto, P. Thanapreedawat, M. Akao, M. Kim, K. Hayase, H. Yokogoshi: Effect of dietary γ–aminobutyric acid on the brain protein synthesis rate in hypophysectomized aged rats. J. Nutr. Sci. Vitaminol. 57(4), 285-291, 2011.

Y. Uekusa, M. Kamihira-Ishijima, O. Sugimoto, T. Ishii, S. Kumazawa, K. Nakamura, K. Tanji, A. Naito, T. Nakayama: Interaction of epicatechin gallate with phospholipid membranes as revealed by solid-state NMR spectroscopy. Biochim. Biophys. Acta. 1808, 1654-1660, 2011.

K. Unno, K. Fujitani, N. Takamori, F. Takabayashi, K.I. Maeda, H. Miyazaki, K. Iguchi, K. Shimoi, M. Hoshino: Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice. Free Radic. Res. 45(8), 966-974, 2011.

T. Wakimoto, H. Kondo, H. Nii, K. Kimura, Y. Egami, Y. Oka, M. Yoshida, E. Kida, Y. Ye, S. Akahoshi, T. Asakawa, K. Matsumura, H. Ishida, H. Nukaya, K. Tsuji, T. Kan, I. Abe: Furan fatty acid as an anti-inflammatory component from green-lipped mussel, Perna canaliculus. Proc. Natl. Acad. Sci. USA, 108, 17533-17537, 2011.

T. Wakimoto, K. Miyata, H. Ouchi, T. Asakawa, H. Nukaya, Y. Suwa, T. Kan: Enantioselective Total Synthesis of Aperidine. Org. Lett. 13, 2789-2791, 2011.

Y. Watanabe, M. S. Ibrahim, H. F. Ellakany, N. Kawashita, R. Mizuike, H. Hiramatsu, N. Sriwilaijaroen, T. Takagi, Y. Suzuki, K. Ikuta: Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt. PLoS Pathogens, 7(5), e-1002068, 2011.

S. Wichit, A. Jittmittraphap, K. I.P.J. Hidari, B. Thaisomboonsuk, S. Petmitr, S. Ubol, C. Aoki, S. Itonori, K. Morita, T. Suzuki, Y. Suzuki, W. Janpangern: Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells. Microbiol. and Immunol. 55, 135-140, 2011.

S. Yamada, K. Shinya, A. Takada, T. Ito, T. Suzuki, Y. Suzuki, Q. Le, M. Ebina, N. Kasai, H. Kida, T. Horimoto, P. Rivailler, L. Chen, R. Donis, Y. Kawaoka: Adaptation of a duck influenza A virus in quail. J. Virol. 86, 1411-1420, 2012.

S. Yamada, M. Seki, M. Ogoda, A. Fukata, M. Nakamura, Y. Ito: Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder. J. Pharmacol. Exp. Ther. 336, 365-371, 2011.

H. Yamaguchi, Y. Hirakura, H. Shirai, H. Mimura, T. Toyo’oka: Quantitative evaluation of protein conformation in pharmaceuticals using cross-linking reactions coupled with LC-MS/MS analysis. J. Pharm. Biomed. Anal. 55, 574-582, 2011.

K. Yamakawa-Kobayashi, M. Natsume, S. Aoki, S. Nakano, T. Inamori, N. Kasezawa, T. Goda: The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study. BMC Med. Genet. in press.

S. Yamamoto, S. Maruyama, Y. Ito, M. Kawamata, S. Nishiyama, H. Ohba, H. Tsukada, S. Yamada: Effect of oxybutynin and imidafenacin on central muscarinic receptor occupancy and cognitive function: A monkey PET study with [11C](+)-3-MPB. NeuroImage. 58, 1-9, 2011.

Y. Yamazaki, T. Hashizume, H. Morioka, S. Sadamitsu, A. Ikari, M. Miwa, J. Sugatani: Diet-induced lipid accumlation in liver enhances ATP-biding cassette transporter g5/g8 expression in bile canaliculi. Drug Metab. Pharmacokinet. 26, 442-450, 2011.

K. Yasui, H. Tanabe, N. Miyoshi, T. Suzuki, S. Goto, K. Taguchi, Y. Ishigami, N. Paeng, R. Fukutomi, S. Imai, M. Isemura: Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum. Biomed. Res. 32, 313-320, 2011.

K. Yasui, N. Miyoshi, H. Tababe, Y. Ishigami, R. Fukutomi, S. Imai, M. Isemura: Effects of Oolong tea on gene expression of gluconeogenic enzymes in the mouse liver and in rat hepatoma H4IIE cells. J. Med. Food, 14, 930-938, 2011. Epub 2011 Aug 3.

K. Yasui, N. Miyoshi, H. Tanabe, Y. Ishigami, R. Fukutomi, S. Imai, M. Isemura: Effects of a catechin-free fraction derived from green tea on gene expression of gluconeogenic enzymes in rat hepatoma H4IIE cells and in the mouse liver. Biomed. Res. 32, 119-125, 2011.

K. Yasui, N. Paeng, N. Miyoshi, T. Suzuki, K. Taguchi, Y. Ishigami, R. Fukutomi, S. Imai, M. Isemura, T. Nakayama: Effects of a catechin-free fraction derived from green tea on gene expression of enzymes related to lipid metabolism in the mouse liver. Biomed. Res. in press.

N. Yonenaga, E. Kenjo, T. Asai, A. Tsuruta, K. Shimizu, T. Dewa, M. Nango, N. Oku: RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment. J. Control. Release, in press.

T. Yoshida, H. Kumagai, A. Suzuki, N. Kobayashi, S. Ohkawa, M. Odamaki, T. Kohsaka, T. Yamamoto, N. Ikegaya: Relaxin ameliorates salt-sensitive hypertension and renal fibrosis. Nephrol Dial. Transplant, 27, Nov.15, 2011.

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